A comprehensive production method of self-cryoprotected nano-liposome powders

International Journal of Pharmaceutics
Rikhav P GalaMohamed A Alhnan

Abstract

This study provided a convenient approach for large scale production of hydrogenated soya phosphatidylcholine nano-liposome powders using beclometasone dipropionate as a model drug and sucrose as proliposome carrier. Fluid-bed coating was employed to manufacture proliposomes by coating sucrose with the phospholipid (5%, 10%, 15% and 20% weight gains), followed by hydration, size reduction using high pressure homogenization, and freeze-drying to yield stable nano-vesicles. High pressure homogenization was compared with probe-sonication in terms of liposome size, zeta potential and drug entrapment. Furthermore, the effect of freeze-drying on vesicle properties generated using both size reduction methods was evaluated. Results have shown that high-pressure homogenization followed by freeze-drying and rehydration tended to yield liposomes smaller than the corresponding vesicles downsized via probe-sonication, and all size measurements were in the range of 72.64-152.50 nm, indicating that freeze-drying was appropriate, regardless of the size reduction technique. The liposomes, regardless of size reduction technique and freeze drying had slightly negative zeta potential values or were almost neutral in surface charge. The entrapment ...Continue Reading

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Citations

Oct 13, 2015·International Journal of Pharmaceutics·Iftikhar KhanAbdelbary Elhissi
Apr 25, 2016·International Journal of Pharmaceutics·Mohammad NajlahAbdelbary M A Elhissi
Nov 12, 2016·Journal of Liposome Research·Mohammad NajlahAbdelbary Elhissi
Aug 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaona LiuDefang Li
Oct 3, 2018·Journal of the Science of Food and Agriculture·Evelyn B RodriguezCharisse T Reyes
Nov 14, 2018·Frontiers in Pharmacology·Gina D KusumaRebecca Lim
Aug 10, 2019·International Journal of Molecular Sciences·Wojciech KałasMarta Kopaczyńska
Jun 8, 2021·International Journal of Pharmaceutics·Xiaojing LiuDaniel Scherman

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