A Comprehensive Review of Aminochalcones.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Rimsha IrfanRahman Shah Zaib Saleem

Abstract

Chalcones, members of the flavonoid family, display a plethora of interesting biological activities including but not limited to antioxidant, anticancer, antimicrobial, anti-inflammatory, and antiprotozoal activities. The literature cites the synthesis and activity of a range of natural, semisynthetic, and synthetic chalcones. The current review comprehensively covers the literature on amino-substituted chalcones and includes chalcones with amino-groups at various positions on the aromatic rings as well as those with amino-groups containing mono alkylation, dialkylation, alkenylation, acylation, and sulfonylation. The aminochalcones are categorized according to their structure, and the corresponding biological activities are discussed as well. Some compounds showed high potency against cancer cells, microbes, and malaria, whereas others did not. The purpose of this review is to serve as a one-stop location for information on the aminochalcones reported in the literature in recent years.

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Citations

May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Luiza ZeraikVanderlan S Bolzani
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yong-Feng GuanSai-Yang Zhang

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Datasets Mentioned

BETA
CBS1526

Methods Mentioned

BETA
acylation
fluorescence-activated cell sorting
acetylation

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