A comprehensive review of clinical trials on the efficacy and safety of drugs for the treatment of low back pain

Journal of Pain and Symptom Management
Thomas J SchnitzerSheldon X Kong

Abstract

A systematic review involving 50 randomized controlled trials (4,863 patients) published since 1980 was undertaken with the objective of assessing efficacy and safety of low back pain (LBP) medications. The methodological quality of each trial was evaluated based on a standardized system. Quality scores ranged from 26 to 82 points on a 100-point scale (from 0 to 100), indicating an overall moderate quality of the trials reviewed. Limited evidence was found regarding the effectiveness of drug treatments for LBP and current studies focused on short-term usage of the therapies. Available evidence supported the effectiveness of non-selective nonsteroidal anti-inflammatory drugs (NSAIDs) in acute and chronic LBP, of muscle relaxants in acute LBP, and of antidepressants in chronic LBP; safety results were heterogeneous. More rigorously designed trials should be implemented to establish comparative efficacy and safety of drugs used to treat chronic and acute LBP.

References

May 1, 1989·Seminars in Arthritis and Rheumatism·M D Brown
Mar 1, 1988·Spine·B E Schnebel, J W Simmons
Jan 1, 1986·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·J P Fulkerson, M A Folcik
Jan 1, 1980·Current Medical Research and Opinion·D P EvansR G Newcombe
Apr 1, 1982·Annals of the Rheumatic Diseases·H BerryD R Swinson
Sep 1, 1995·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·J N Katz, V Gall
Jan 27, 1997·The American Journal of Medicine·D G Borenstein
Dec 22, 1999·Pain·Nikolaos Maniadakis, Alastair Gray
Aug 11, 2000·The American Journal of Medicine·S ChrubasikC Conradt
Jun 8, 2002·JAMA : the Journal of the American Medical Association·Ethan M BalkJoseph Lau
Dec 13, 2005·The Clinical Journal of Pain·Ilse E J Swinkels-MeewisseJohan W S Vlaeyen
Apr 26, 2006·The American Journal of Emergency Medicine·Gregory A VolturoRichard Aghababian
Jun 21, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Steven K DobschaMartha S Gerrity
Aug 18, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Walter J Finnegan
Jan 1, 1993·Journal of Back and Musculoskeletal Rehabilitation·E W Johnson

❮ Previous
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Citations

Jan 11, 2005·Arthritis and Rheumatism·David Borenstein
Oct 29, 2004·Current Pain and Headache Reports·David Borenstein
May 27, 2009·Current Reviews in Musculoskeletal Medicine·David S Binder, Devi E Nampiaparampil
May 27, 2009·Current Reviews in Musculoskeletal Medicine·Kimberley Middleton, David E Fish
Dec 17, 2009·Photomedicine and Laser Surgery·Ljubica M KonstantinovicNesa D Milovanovic
Feb 28, 2007·Anesthesiology·Steven P Cohen, Srinivasa N Raja
Jun 15, 2006·The Clinical Journal of Pain·YiLi Zhou, Salahadin Abdi
May 24, 2012·Pain Research and Treatment·Carlo Luca RomanòMarco Lacerenza
Sep 28, 2012·Sports Health·Ryan C Petering, Charles Webb
Nov 19, 2013·Revista da Associação Médica Brasileira·UNKNOWN Associação Brasileira de Medicina Física e Reabilitação
Dec 3, 2014·Advanced Drug Delivery Reviews·S B G BlanquerA A Poot
Apr 2, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jessica J WongAnne Taylor-Vaisey
Oct 5, 2011·Spine·Andrew P WhiteMichael G Fehlings
Oct 28, 2008·Progress in Neurobiology·A Vania ApkarianPaul Y Geha
Jul 22, 2008·Rheumatic Diseases Clinics of North America·Serge PerrotFrançoise Laroche
Jan 1, 2008·The Spine Journal : Official Journal of the North American Spine Society·Gerard Malanga, Erin Wolff
Jan 1, 2008·The Spine Journal : Official Journal of the North American Spine Society·Victor ChangVenu Akuthota
Apr 18, 2006·Physical Medicine and Rehabilitation Clinics of North America·Carin E Dugowson, Priya Gnanashanmugam
Jul 30, 2010·Pain Practice : the Official Journal of World Institute of Pain·Maarten van KleefNagy Mekhail
Mar 19, 2011·Journal of Clinical Pharmacology·Pinky DharmshaktuBhupinder Singh Kalra
Jan 28, 2014·Pain Practice : the Official Journal of World Institute of Pain·Owen D WilliamsonAlexander Schacht
Sep 19, 2006·Best Practice & Research. Clinical Rheumatology·Shari Diamond, David Borenstein
Oct 6, 2005·The Journal of Pain : Official Journal of the American Pain Society·Jennifer KatzRobert H Dworkin
Sep 7, 2016·The Journal of Orthopaedic and Sports Physical Therapy·Michele Curatolo
Feb 7, 2008·The Cochrane Database of Systematic Reviews·D M UrquhartM W van Tulder
May 1, 2008·Rheumatology·S PerrotUNKNOWN CEDR (Cercle d'Etude de la Douleur en Rhumatologie France), French Rheumatological Society, Pain Study Section
Jul 22, 2005·The British Journal of Surgery·J A MichaelsS M Thomas
Feb 9, 2008·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S M Elahi, F Odejinmi
Jan 25, 2020·BMC Medical Research Methodology·Mohammad Hossein PanahiFahimeh Ramezani Tehrani
Mar 24, 2017·Family Practice·Jacoline J van den DriestDieuwke Schiphof
Sep 13, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Ke MaYan-Qing Liu
Apr 1, 2006·CNS Spectrums·Jeffrey L JacksonKurt Kroenke
Aug 30, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabio ColellaLaura B Creemers

❮ Previous
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