Since 1943, cases of sensitization or allergy to soy-based formulas (SBFs) have been described without any consensus on their real prevalence. We identified the adjusted prevalence of IgE-mediated soy allergies in children and performed a secondary analysis of the impact of age (less than and more than 6 months). We performed a systematic review with meta-analysis of studies published from 1909 to 2013 in PubMed, Embase, LILACS, ARTEMISA, Cochrane, Bandolier, DARE and the GRADE system for grading quality. Results are presented in tables and graphs using a forest plot. The 40 studies identified established weighted prevalence of soy allergies of 0 to 0.5 % (0.27) for the general population, 0.4 to 3.1 % (1.9) for the referred population, and 0 to 12.9 % (2.7) for allergic children. Prevalence of sensitization after the use of SBFs is 8.7 and 8.8 %, depending on the method used. The prevalence of allergies to soy and IgE sensitization to the use of SBFs is less than reported. Not enough evidence exists to show a higher risk of allergy in infants younger than 6 months. The concern about soy allergy is no reason to postpone the use of SBFs in IgE-mediated cow's milk allergy infants until the age of 6 months.
Soy versus cow's milk in infants with a biparental history of atopic disease: development of atopic disease and immunoglobulins from birth to 4 years of age
Diagnostic criteria for food allergy with predominantly intestinal symptoms. The European Society for Paediatric Gastroenterology and Nutrition Working Group for the Diagnostic Criteria for Food Allergy
Patterns of food hypersensitivity during sixteen years of double-blind, placebo-controlled food challenges
A prospective study of cow milk allergy in Danish infants during the first 3 years of life. Clinical course in relation to clinical and immunological type of hypersensitivity reaction
Experience with intracorporeal injection of papaverine and duplex ultrasound scanning for assessment of arteriogenic impotence
Morphometric and immunohistochemical study of jejunal biopsies from children with intestinal soy allergy
Safety of a new, ultrafiltrated whey hydrolysate formula in children with cow milk allergy: a clinical investigation
Bone mineralization in the first year of life in infants fed human milk, cow-milk formula, or soy-based formula
Natural history of soy allergy and/or intolerance in children, and clinical use of soy-protein formulas
Outcome of double-blind, placebo-controlled food challenge tests in 107 children with atopic dermatitis
Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study
Allergy to soy formula and to extensively hydrolyzed whey formula in infants with cow's milk allergy: a prospective, randomized study with a follow-up to the age of 2 years
Food allergy is a matter of geography after all: sesame as a major cause of severe IgE-mediated food allergic reactions among infants and young children in Israel
Development of a highly sensitive search strategy for the retrieval of reports of controlled trials using PubMed
Evaluation of infants fed soybean and evaporated milk formulae from birth to three months. A comparison of weight, length, hemoglobin, hematocrit, and plasma biochemical values
Developing optimal search strategies for detecting clinically sound prognostic studies in MEDLINE: an analytic survey
Feeding a soy formula to children with cow's milk allergy: the development of immunoglobulin E-mediated allergy to soy and peanuts
Growth of infants with IgE-mediated cow's milk allergy fed different formulas in the complementary feeding period
Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas
Primary versus secondary immunoglobulin E sensitization to soy and wheat in the Multi-Centre Allergy Study cohort
A new protocol for specific oral tolerance induction in children with IgE-mediated cow's milk allergy
Functional gastro-intestinal disorder algorithms focus on early recognition, parental reassurance and nutritional strategies
Time to symptom improvement using elimination diets in non-IgE-mediated gastrointestinal food allergies
Assessment of endogenous allergenicity of genetically modified plants exemplified by soybean - Where do we stand?
Middle East Consensus Statement on the Prevention, Diagnosis, and Management of Cow's Milk Protein Allergy
Non-Dairy Fermented Beverages as Potential Carriers to Ensure Probiotics, Prebiotics, and Bioactive Compounds Arrival to the Gut and Their Health Benefits.
Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition
Efficacy of Soy-Based Formulas in Alleviating Gastrointestinal Symptoms in Infants With Milk-Based Formula Intolerance: A Randomized Clinical Trial.
Non-animal proteins as cutting-edge ingredients to reformulate animal-free foodstuffs: Present status and future perspectives.
The role of soy plant-based formula supplemented with dietary fiber to support children's growth and development: An expert opinion.
Consensus statement on the epidemiology, diagnosis, prevention, and management of cow's milk protein allergy in the Middle East: a modified Delphi-based study.
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.