A comprehensive review of the diagnosis and management of prosthetic joint infections in the absence of positive cultures

Journal of Infection and Public Health
Monisha S Parikh, Suresh Antony

Abstract

The diagnosis and management of prosthetic joint infections (PJI) with negative cultures remains an enigma without clear definitions and guidelines for its management. In contrast, the literature offers guidelines to the diagnosis and management of culture positive prosthetic joint infections as noted in both the infectious disease literature and the orthopedic literature. This paper outlines the current state of knowledge of PJI with negative cultures and summarizes the recommendations for the work up and management of this condition. In addition, we propose a simple algorithm that clinicians may find useful for the management of PJI with negative cultures. This algorithm has not been validated with data at this point, but can be applied to practice to help direct the management and diagnosis of prosthetic joint infections in the absence of positive cultures.

References

Apr 1, 1984·The Journal of Clinical Investigation·W ZimmerliF A Waldvogel
Nov 25, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E F BerbariD R Osmon
Apr 12, 2003·Infection·W Zimmerli, P E Ochsner
Oct 16, 2004·The New England Journal of Medicine·Werner ZimmerliPeter E Ochsner
Mar 25, 2005·Acta Orthopaedica·Daniëlle NeutHenk J Busscher
Jun 27, 2006·The Journal of Bone and Joint Surgery. British Volume·J E PhillipsR J Grimer
Aug 19, 2007·The New England Journal of Medicine·Andrej TrampuzRobin Patel
Oct 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elie F BerbariDouglas R Osmon
Jul 12, 2008·International Journal of Antimicrobial Agents·Silvano Esposito, Sebastiano Leone
Sep 10, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C A AboltinsP A Stanley
May 24, 2011·Seminars in Immunopathology·Werner Zimmerli, Parham Sendi
Jun 7, 2011·The Journal of Arthroplasty·Benjamin ZmistowskiJavad Parvizi
Aug 9, 2011·The Journal of Hospital Infection·T N PeelK L Buising
Sep 12, 2012·Current Opinion in Infectious Diseases·Trisha N PeelPeter F M Choong
Dec 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Douglas R OsmonUNKNOWN Infectious Diseases Society of America
Jun 19, 2013·International Orthopaedics·Przemysław L BerezaGayane Martirosian
Jul 28, 2013·The Journal of Arthroplasty·Alexander DeHaanPenelope Barnes
Sep 21, 2013·Scandinavian Journal of Infectious Diseases·Seung-Ju Kim, Jong Hun Kim
Nov 30, 2013·TheScientificWorldJournal·Laurence Legout, Eric Senneville
Dec 7, 2013·BioMed Research International·María Eugenia PortilloAndrej Trampuz
Feb 11, 2014·Enfermedades infecciosas y microbiología clínica·Concepción Pérez-JorgeJaime Esteban-Moreno
Mar 7, 2014·The Journal of Bone and Joint Surgery. American Volume·Javad ParviziCraig J Della Valle
Mar 13, 2014·Journal of Internal Medicine·W Zimmerli
Mar 25, 2014·Clinical Orthopaedics and Related Research·Charles L NelsonThomas R Bowen
Mar 26, 2014·The American Journal of Medicine·Matthieu MillionDidier Raoult
Mar 29, 2014·Journal of Clinical Microbiology·John J FarrellRobin Patel
Apr 2, 2014·Orthopedics·David M BennettMichael D Miller
Apr 17, 2014·International Orthopaedics·Gerrit Steffen MaierUwe Maus
Apr 20, 2014·Clinical Orthopaedics and Related Research·Colten D BrackenRafael J Sierra
Jun 9, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Mohamed N RahamanWenhai Huang
Aug 20, 2014·The Journal of Antimicrobial Chemotherapy·Lucinda Barrett, Bridget Atkins
Aug 20, 2014·The Journal of Antimicrobial Chemotherapy·Cédric Jacqueline, Jocelyne Caillon
Aug 20, 2014·The Journal of Antimicrobial Chemotherapy·Theresa Lamagni
Oct 29, 2014·Annals of the Royal College of Surgeons of England·T A CannonI Stockley
Mar 25, 2015·Journal of Chemotherapy·Silvano EspositoMario Venditti

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Citations

Feb 1, 2019·Journal of Medical Microbiology·Hussein AbdelazizMustafa Citak
Feb 19, 2019·Journal of Leukocyte Biology·Brittney N V ScottAjitha Thanabalasuriar
Oct 9, 2019·Antibiotics·Maciej JaśkiewiczWojciech Kamysz
Mar 27, 2019·International Review of Psychiatry·Rheanna E PlattLawrence S Wissow
Nov 23, 2019·EFORT Open Reviews·Jeya PalanPedro Foguet
Sep 11, 2020·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Christian LausmannAkos Zahar
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Diana AlvesMaria Olívia Pereira
Mar 8, 2021·BMC Musculoskeletal Disorders·Han YinDawei Wang
Mar 2, 2021·Expert Review of Molecular Diagnostics·Zakareya GamieEleftherios Tsiridis
Jul 23, 2021·The Journal of Bone and Joint Surgery. American Volume·Adriana P EcheverriaLaura T Donlin

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