A Comprehensive Review of the Pharmacologic Management of Uterine Leiomyoma

BioMed Research International
Terrence D LewisWilliam H Catherino

Abstract

Uterine leiomyomata are the most common benign tumors of the gynecologic tract impacting up to 80% of women by 50 years of age. It is well established that these tumors are the leading cause for hysterectomy with an estimated total financial burden greater than $30 billion per year in the United States. However, for the woman who desires future fertility or is a poor surgical candidate, definitive management with hysterectomy is not an optimal management plan. Typical gynecologic symptoms of leiomyoma include infertility, abnormal uterine bleeding (AUB)/heavy menstrual bleeding (HMB) and/or intermenstrual bleeding (IMB) with resulting iron-deficiency anemia, pelvic pressure and pain, urinary incontinence, and dysmenorrhea. The morbidity caused by these tumors is directly attributable to increases in tumor burden. Interestingly, leiomyoma cells within a tumor do not rapidly proliferate, but rather the increase in tumor size is secondary to production of an excessive, stable, and aberrant extracellular matrix (ECM) made of disorganized collagens and proteoglycans. As a result, medical management should induce leiomyoma cells toward dissolution of the extracellular matrix, as well as halting or inhibiting cellular proliferation. H...Continue Reading

References

Oct 1, 1990·American Journal of Clinical Pathology·S F Cramer, A Patel
Dec 1, 1988·Obstetrics and Gynecology·F ParazziniL Fedele
Dec 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S E BulunE R Simpson
Aug 1, 1993·The Journal of Clinical Endocrinology and Metabolism·T J IvesonM Dowsett
Mar 25, 1993·The New England Journal of Medicine·K J CarlsonI Schiff
Feb 1, 1993·The Journal of Clinical Endocrinology and Metabolism·A A MurphyS S Yen
Nov 18, 1997·Human Reproduction·D Gonzalez-BarcenaH Riethmüller-Winzen
Dec 16, 1997·Obstetrics and Gynecology·L M MarshallD J Hunter
Feb 19, 1999·Baillière's Clinical Obstetrics and Gynaecology·B Vollenhoven
Oct 19, 2000·Environmental Health Perspectives·S M SchwartzD D Baird
Apr 30, 2002·Obstetrics and Gynecology·Eric S Surrey, Mark D Hornstein
Jan 14, 2003·Fertility and Sterility·Gaylene PronUNKNOWN Ontario Uterine Fibroid Embolization Collaboration Group
Jan 28, 2003·American Journal of Obstetrics and Gynecology·Donna Day BairdJoel M Schectman
Feb 11, 2003·Obstetrics and Gynecology·Steven H EisingerDavid S Guzick
Jun 27, 2003·Drugs·Keri Wellington, Antona J Wagstaff
Dec 31, 2003·Contraception·Regine Sitruk-Ware, Irving M Spitz
May 7, 2004·Current Opinion in Obstetrics & Gynecology·David L OliveElizabeth A Pritts
Jun 3, 2004·Obstetrics and Gynecology·Jody SteinauerAlison F Jacoby
Aug 5, 2004·Obstetrics and Gynecology·Edward E Wallach, Nikos F Vlahos
Jan 18, 2005·Autoimmunity Reviews·Jill P Buyon, Robert M Clancy
Mar 15, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S VenkatachalamJ Moodley
Apr 22, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·P A FliermanS de Blok
Jun 1, 2005·Journal of Minimally Invasive Gynecology·Steven H EisingerDavid S Guzick
Oct 20, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·G Attilakos, R Fox
Dec 13, 2005·Journal of Minimally Invasive Gynecology·Jacqueline N Gutmann, Stephen L Corson
Jul 17, 2007·Human Reproduction Update·Frances McFarland Horne, Diana L Blithe
Sep 4, 2007·Obstetrics and Gynecology·Fotios K VarelasGeorgios D Vlassis
Nov 6, 2007·Obstetrics and Gynecology·Jennifer M WuAnthony G Visco
Feb 6, 2008·Fertility and Sterility·Sandro G HilárioEdmund C Baracat
Apr 9, 2008·American Journal of Obstetrics and Gynecology·Peter C KlatskyVictor Y Fujimoto
May 2, 2008·Obstetrics and Gynecology·Eric D LevensLynnette K Nieman
Jun 7, 2008·Best Practice & Research. Clinical Obstetrics & Gynaecology·Stanley Okolo

❮ Previous
Next ❯

Citations

Dec 28, 2018·Expert Opinion on Therapeutic Patents·Sávia Francisca Lopes DiasLívio César Cunha Nunes
Feb 6, 2020·International Journal of Environmental Research and Public Health·Iwona SzydłowskaAndrzej Starczewski
Feb 6, 2020·Reproductive Sciences·Minnie MalikWilliam H Catherino
Aug 6, 2020·International Journal of Molecular Sciences·Michał CiebieraAyman Al-Hendy
Feb 18, 2021·The New England Journal of Medicine·Ayman Al-HendyElizabeth A Stewart
Feb 13, 2021·Obstetrics and Gynecology Clinics of North America·Stephanie NougaretJessica B Robbins
Feb 12, 2020·Radiologic Clinics of North America·Stephanie NougaretJessica Robbins
Apr 16, 2021·Nature Reviews. Endocrinology·Donna D Baird, Quaker E Harmon

❮ Previous
Next ❯

Methods Mentioned

BETA
hysterectomies
hysterectomy
Contraception
biopsies
RNAseq

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

© 2022 Meta ULC. All rights reserved