A Comprehensive Review of Trigeminal Neuralgia

Current Pain and Headache Reports
Mark R JonesOmar Viswanath

Abstract

Trigeminal neuralgia (TN) is characterized by recurrent attacks of lancinating facial pain in the dermatomal distribution of the trigeminal nerve. TN is rare, affecting 4 to 13 people per 100,000. Although there remains a debate surrounding the pathogenesis of TN, neurovascular compromise is the most currently accepted theory. Minimal stimulation caused by light touch, talking, or chewing can lead to debilitating pain and incapacitation of the patient. Pain may occur sporadically, though is primarily unilateral in onset. The diagnosis is typically determined clinically. Treatment options include medications, surgery, and complementary approaches. Anti-epileptic and tricyclic antidepressant medications are first-line treatments. Surgical management of patients with TN may be indicated in those who have either failed medical treatment with at least three medications, suffer from intolerable side-effects, or have non-remitting symptoms. Surgical treatment is categorized as either destructive or non-destructive. Deep brain and motor cortex neuro-modulatory stimulation are off label emerging techniques which may offer relief to TN that is otherwise refractory to pharmacological management and surgery. Still, sufficient data has yet ...Continue Reading

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Citations

May 10, 2020·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Juliana Araújo OliveiraLívia Maria Sales Pinto Fiamengui
Jan 8, 2020·Molecular Pain·Eder GambetaGerald W. Zamponi
Dec 19, 2020·Clinical Neurology and Neurosurgery·Cynthia A SmithAntonios Mammis
Jan 31, 2021·Molecular Neurobiology·Yuhui LuoYong Chen
Mar 19, 2021·Acta Neurologica Scandinavica·Christian Barro, Henrik Zetterberg
Mar 23, 2021·Headache·Javier Molina-GilCarmen García-Cabo
Apr 7, 2021·Current Pain and Headache Reports·Chen ZengHan-Feng Yang
Apr 13, 2021·Frontiers in Neuroscience·Seoyon YangMin Cheol Chang
May 29, 2021·Continuum : Lifelong Learning in Neurology·Carrie Robertson
Aug 5, 2021·Surgical Neurology International·Mohamad El HoushiemyHoussein Darwish
Jul 29, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Bing HuangXiang Qian

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