A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development

Drug Metabolism and Pharmacokinetics
Shingo OdaMiki Nakajima

Abstract

UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze the transfer of glucuronic acid to hydroxyl, carboxyl, or amine groups of compounds, whereas esterases hydrolyze compounds that contain ester, amide, and thioester bonds. These enzymes, in most cases, convert hydrophobic compounds to water-soluble metabolites to facilitate the elimination of compounds from the body. Information about these enzymes is steadily increasing, although our knowledge is still behind our understanding of P450. This review gives an overview of recent findings in UGT and esterases studies focusing on tissue distribution, gene regulation, substrate and inhibitor specificity, and species differences. In particular, the absolute protein content of UGT isoforms and esterases in human tissues could be available. In the field of esterases, it is becoming clear that enzymes other than carboxylesterase are involved in drug hydrolysis. In addition, there is an interesting interplay between UGTs and esterases in the formation and hydrolytic deglucuronidation of acyl-glucuronide, which is considered to be a reactive metabolite. With the growing aw...Continue Reading

References

May 1, 1977·Life Sciences·D J StewartW Kalow
May 31, 1991·Biochemical and Biophysical Research Communications·M R ProbstU A Meyer
Apr 1, 1989·Anesthesia and Analgesia·D R CookR M Welch
Aug 1, 1988·British Journal of Anaesthesia·F Pérez GuillermoC J Vidal
Mar 1, 1986·Endocrinology·C A Lamartiniere
Mar 1, 1986·The Journal of Clinical Investigation·P C SmithL Z Benet
May 1, 1981·Endocrinology·N P Illsley, C A Lamartiniere
Nov 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·O JbiloO Lockridge
Sep 15, 1994·Biochemical Pharmacology·Y S HuangL G Sultatos
Apr 1, 1993·Acta Anaesthesiologica Scandinavica·D OstergaardJ Viby-Mogensen
Aug 23, 1996·Biochemical and Biophysical Research Communications·B MojarrabiP I Mackenzie
May 15, 1997·Archives of Biochemistry and Biophysics·C J JinJ O Miners
Feb 19, 1998·Archives of Biochemistry and Biophysics·P A MünzelK W Bock
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·J H KimS Grinstein
Aug 29, 1998·Archives of Biochemistry and Biophysics·D PhelanM S Denison
Jun 25, 1999·Biochemical and Biophysical Research Communications·M CiottiI S Owens
Oct 21, 1999·The Journal of Steroid Biochemistry and Molecular Biology·W E GallA Radominska-Pandya
Jan 25, 2000·The Journal of Biological Chemistry·T HirohashiY Sugiyama
Mar 29, 2001·Journal of Pharmaceutical and Biomedical Analysis·N HaniokaM Ando
May 4, 2001·American Journal of Human Genetics·V H BrophyC E Furlong
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·M G SoarsR J Riley
Apr 16, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Thomayant PrueksaritanontThomas A Baillie
May 23, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Daniel C KempJeffrey C Stevens
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Thomayant PrueksaritanontThomas A Baillie
Sep 17, 2002·European Journal of Biochemistry·Sonal P SanghaniWilliam F Bosron
Oct 10, 2002·Endocrine Reviews·Steven A KliewerTimothy M Willson
Oct 19, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Thomayant PrueksaritanontJiunn H Lin
Nov 16, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yuichiro WatanabeTsuyoshi Yokoi

❮ Previous
Next ❯

Citations

Sep 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea MattareiCristina Paradisi
Jan 26, 2016·Pharmacology & Therapeutics·Zofia MazerskaEwa Augustin
Jan 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Eva DazertMichael N Hall
Jun 22, 2016·Drug Metabolism and Pharmacokinetics·Pimsumon JiamboonsriMing Hu
Apr 27, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Atsushi IwamuraTsuyoshi Yokoi
Jul 1, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Xin LiuHong-Zhi Sun
Apr 17, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Matthew A Cerny
Sep 10, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Celia Lloret-LinaresXavier Declèves
Aug 16, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Milu T CherianTaosheng Chen
Dec 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ruixue RanZhongze Fang
Apr 30, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Takamitsu KondoMayumi Ishizuka
Mar 14, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Da-Wei ChenZhong-Ze Fang
Jun 28, 2017·Journal of Medicinal Chemistry·José M EstrelaRyan W Dellinger
Jun 29, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Toshito NakagawaMasaki Ishigai
Jun 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dan SunZhong-Ze Fang
Feb 10, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Byoung Hoon YouYoung Hee Choi
Sep 16, 2017·Drug Metabolism Reviews·Mei ZengJingqing Zhang
Dec 19, 2017·Expert Opinion on Drug Metabolism & Toxicology·Sang Hoon LeeHyo-Kyung Han
May 16, 2018·Pest Management Science·Robert D Clark
Jun 2, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Miki Nakajima
Jan 13, 2019·Biopharmaceutics & Drug Disposition·Pil Joung ChoSangkyu Lee
Apr 1, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Deepak Kumar BhattBhagwat Prasad
Mar 31, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jiamei ChenZhongqiu Liu
Jul 13, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Shingo OdaMiki Nakajima
Sep 13, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·J Matthew HutzlerShelby R Anderson
Dec 17, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Nicolo MilaniStephen Fowler
Jun 25, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Youn Ah KimSangkyu Lee
Jan 2, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ian CookThomas S Leyh
Aug 20, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Mizuki YamaneToshito Nakagawa
Sep 16, 2019·Journal of Molecular Evolution·Marie Saitou, Omer Gokcumen
May 26, 2017·European Journal of Drug Metabolism and Pharmacokinetics·Ruiya ZhangZhonghui Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Related Papers

Drug Metabolism and Pharmacokinetics
Tatsuki Fukami, Tsuyoshi Yokoi
Applied Microbiology and Biotechnology
Takuya KosekiMichio Komai
Current Drug Metabolism
Anna Radominska-PandyaP J Czernik
© 2021 Meta ULC. All rights reserved