A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment.

Frontiers in Immunology
Kunal PratapSandip D Kamath

Abstract

Food allergy is rising at an alarming rate and is a major public health concern. Globally, food allergy affects over 500 million people, often starting in early childhood and increasingly reported in adults. Commercially, only one approved oral immunotherapy-based treatment is currently available and other allergen-based immunotherapeutic are being investigated in clinical studies. As an alternative approach, a substantial amount of research has been conducted on natural compounds and probiotics, focusing on the immune modes of action, and therapeutic uses of such sources to tackle various immune-related diseases. Food allergy is primarily mediated by IgE antibodies and the suppression of allergic symptoms seems to be mostly modulated through a reduction of allergen-specific IgE antibodies, upregulation of blocking IgG, and downregulation of effector cell activation (e.g., mast cells) or expression of T-helper 2 (Th-2) cytokines. A wide variety of investigations conducted in small animal models or cell-based systems have reported on the efficacy of natural bioactive compounds and probiotics as potential anti-allergic therapeutics. However, very few lead compounds, unlike anti-cancer and anti-microbial applications, have been se...Continue Reading

References

Oct 1, 1994·International Journal of Biological Macromolecules·A K SenD K Ganguly
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B BjörksténM Mikelsaar
Jan 6, 2000·Regulatory Toxicology and Pharmacology : RTP·I G Carabin, W G Flamm
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y ShibataQ N Myrvik
Oct 26, 2000·Thorax·A Huntley, E Ernst
Nov 23, 2000·Biochimica Et Biophysica Acta·Y HayakawaN Sakuragawa
Oct 9, 2001·The Journal of Allergy and Clinical Immunology·X M LiH A Sampson
May 14, 2003·The Journal of Allergy and Clinical Immunology·Vivian MorafoAndXiu-Min Li
Oct 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J M DavisE P Mayer
Feb 21, 2004·International Archives of Allergy and Immunology·Tadashi YoshidaMakoto Hattori
Jun 29, 2004·Journal of Clinical Gastroenterology·M Miraglia del Giudice, M G De Luca
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Kamal D SrivastavaXiu-Min Li
Feb 8, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ching Hsaing HsuTung Ti Chang
Mar 12, 2005·Cellular Microbiology·Gordon D Brown, Siamon Gordon
Apr 16, 2005·Science·Paul B EckburgDavid A Relman
Jun 23, 2005·International Archives of Allergy and Immunology·Hiroko MaruyamaTakahisa Nakano
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Ming-Chun WenXiu-Min Li
Oct 26, 2005·Bioscience, Biotechnology, and Biochemistry·Kenji IshiharaToshihiko Muraoka
Apr 19, 2006·Phytotherapy Research : PTR·Tung-Ti ChangChing-Hsiang Hsu
Jun 10, 2006·The American Journal of Clinical Nutrition·Robert J BoyleMimi L K Tang
Jul 19, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Chin-Kan ChanJing-Long Huang
Aug 10, 2006·European Journal of Immunology·Sofia OstmanEsbjörn Telemo
Oct 10, 2006·Biochemical and Biophysical Research Communications·Souichi OomizuMichihiro Hide
Oct 13, 2006·JAMA : the Journal of the American Medical Association·Daniel G Hackam, Donald A Redelmeier
Dec 8, 2006·Bioscience, Biotechnology, and Biochemistry·Tsukasa UnoTadashi Yoshida
Mar 27, 2007·Allergology International : Official Journal of the Japanese Society of Allergology·Shinobu FujitaniKazuo Itabashi
Apr 14, 2007·Current Pharmaceutical Design·Rainer HartmannAnne-Kathrin Pentzien
May 23, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C QuX-M Li
Jul 25, 2007·Allergology International : Official Journal of the Japanese Society of Allergology·Akiko ToriiHiroichi Nagai
Jan 29, 2008·Physiology & Behavior·Julia J VolmanJogchum Plat
Apr 3, 2008·Journal of Immunotoxicology·M Novak, V Vetvicka
May 8, 2008·Clinical and Experimental Immunology·H IshikawaT Matsumoto
Sep 17, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo LiRuixiang Zhao
Oct 14, 2008·International Archives of Allergy and Immunology·Takeshi YamamotoMakoto Kadowaki
Jan 14, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sun-Yup ShimSe-Kwon Kim
Jul 18, 2009·Biochemical and Biophysical Research Communications·Yuhki YanaseMichihiro Hide
Sep 22, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·L S CostaH A O Rocha
Oct 1, 2009·Regulatory Toxicology and Pharmacology : RTP·Paul Baldrick
Feb 24, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A W ZuercherA Mercenier
Aug 18, 2010·Journal of Ethnopharmacology·Maho SumiyoshiYoshiyuki Kimura

❮ Previous
Next ❯

Citations

Jan 26, 2021·Bioresource Technology·Poonam SharmaJonathan W C Wong
Jan 31, 2021·International Journal of Environmental Research and Public Health·Lidia Stasiak-RóżańskaMonika Garbowska
Mar 12, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Michael A GoldingJennifer L P Protudjer
Aug 20, 2021·Current Opinion in Gastroenterology·Noor Hidayatul Aini SuainiElizabeth Huiwen Tham

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage

Software Mentioned

PAINS
ARRIVE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Jeppe Madura Larsen, Katrine Lindholm Bøgh
European Journal of Immunology
Marine MicheletLaurent L Reber
Arerugī = [Allergy]
Koji Nomoto
© 2021 Meta ULC. All rights reserved