A comprehensive review on zinc(II) complexes as anti-diabetic agents: The advances, scientific gaps and prospects.

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Chika Ifeanyi ChukwumaLimpho M Ramorobi

Abstract

Zinc has gained notable attention in the development of potent anti-diabetic agents, due to its role in insulin storage and secretion, as well as its reported insulin mimetic properties. Consequently, zinc(II) has been complexed with numerous organic ligands as an adjuvant to develop anti-diabetic agents with improved and/or broader scope of pharmacological properties. This review focuses on the research advances thus far to identify the major scientific gaps and prospects. Peer-reviewed published data on the anti-diabetic effects of zinc(II) complexes were sourced from different scientific search engines, including, but not limited to "PubMed", "Google Scholar", "Scopus" and ScienceDirect to identify potent anti-diabetic zinc(II) complexes. The complexes were subcategorized according to their precursor ligands. A critical analysis of the outcomes from published studies shows promising leads, with Zn(II) complexes having a "tri-facet" mode of exerting pharmacological effects. However, the promising leads have been flawed by some major scientific gaps. While zinc(II) complexes of synthetic ligands with little or no anti-diabetic pharmacological history remain the most studied (about 72 %), their toxicity profile was not reported...Continue Reading

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Citations

Jul 28, 2020·Frontiers in Medicine·Leônidas Oliveira NetoKenio Costa Lima
Jun 11, 2021·The Journal of Pharmacy and Pharmacology·Ifedolapo M OkeChika I Chukwuma
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Melyssa L GrieveBrett M Paterson

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