A Comprehensive Screening of Escherichia coli Isolates from Scandinavia's Largest Sewage Treatment Plant Indicates No Selection for Antibiotic Resistance

Environmental Science & Technology
Carl-Fredrik FlachD G Joakim Larsson

Abstract

There is concern that sewage treatment plants (STPs) serve as hotspots for emergence and selection of antibiotic resistant bacteria. However, field studies investigating resistance selection by comparing bacterial populations in influents and effluents have produced variable and sometimes contradictive results. Also, large taxonomic changes between influents and effluents make interpretation of studies measuring relative gene abundances ambiguous. The aim here was to investigate whether within-species selection occurs by conducting a comprehensive screening of Escherichia coli isolated from composite influent and effluent samples collected at Scandinavia's largest STP, accompanied by analyses of antibiotics residues. In total, 4028 isolates, collected on eight occasions during 18 months, were screened for resistance to seven antibiotics. Although differences in proportions of resistant E. coli between influent and effluent samples were detected for a few antibiotics on two occasions, aggregated data over time showed no such differences for any of the investigated antibiotics. Neither was there any enrichment of multiresistant or extended-spectrum beta-lactamase-producing isolates through the treatment process. Despite some anti...Continue Reading

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Citations

May 6, 2019·Environmental Science and Pollution Research International·Ning DingYingxue Sun
Aug 4, 2020·Journal of Applied Microbiology·A KolokotsaE Sazakli
Sep 6, 2020·Environment International·Nadine KraupnerD G Joakim Larsson
Feb 17, 2021·Environment International·Nadine KraupnerD G Joakim Larsson
Feb 26, 2021·Environmental Pollution·Marion HutinelCarl-Fredrik Flach
Jun 3, 2021·Antibiotics·Timo Homeier-BachmannKatharina Schaufler
Nov 6, 2021·Nature Reviews. Microbiology·D G Joakim Larsson, Carl-Fredrik Flach

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