Apr 29, 2015

A comprehensive study of the harmful effects of ZnO nanoparticles using Drosophila melanogaster as an in vivo model

Journal of Hazardous Materials
Mohamed AlarabyRicard Marcos

Abstract

This study planned to determine the range of biological effects associated with ZnO-NP exposure using Drosophila melanogaster as an in vivo model. In addition, ZnCl2 was used to determine the potential role of Zn ions alone. Toxicity, internalization through the intestinal barrier, gene expression changes, ROS production, and genotoxicity were the end-points evaluated. No toxicity or oxidative stress induction was observed in D. melanogaster larvae, whether using ZnO-NPs or ZnCl2. Internalization of ZnO-NPs through the intestinal barrier was observed. No significant changes in the frequency of mutant clones (wing-spot test) or percentage of DNA in tail (comet assay) were observed although significant changes in Hsp70 and p53 gene expression were detected. Our study shows that ZnO-NPs do not induce toxicity or genotoxicity in D. melanogaster, although uptake occurs and altered gene expression is observed.

Mentioned in this Paper

TP53 gene
Study
In Vivo
Chinese Hamster
Exertion
Abdominal Cavity
Hydrogen Peroxide
Heat-Shock Proteins 70
Systemic Inflammatory Response Syndrome
Microvilli

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