A Computational Account of the Role of Cochlear Nucleus and Inferior Colliculus in Stabilizing Auditory Nerve Firing for Auditory Category Learning

Neural Computation
Irina HigginsJan Schnupp


It is well known that auditory nerve (AN) fibers overcome bandwidth limitations through the volley principle, a form of multiplexing. What is less well known is that the volley principle introduces a degree of unpredictability into AN neural firing patterns that may be affecting even simple stimulus categorization learning. We use a physiologically grounded, unsupervised spiking neural network model of the auditory brain with spike time dependent plasticity learning to demonstrate that plastic auditory cortex is unable to learn even simple auditory object categories when exposed to the raw AN firing input without subcortical preprocessing. We then demonstrate the importance of nonplastic subcortical preprocessing within the cochlear nucleus and the inferior colliculus for stabilizing and denoising AN responses. Such preprocessing enables the plastic auditory cortex to learn efficient robust representations of the auditory object categories. The biological realism of our model makes it suitable for generating neurophysiologically testable hypotheses.


Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·D DebanneS M Thompson
Feb 21, 1998·Journal of Neurophysiology·M J FerragamoD Oertel
Jul 29, 2000·Hearing Research·A Recio, William S Rhode
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·D OertelP X Joris
Apr 9, 2002·Brain Research·Sohei ChimotoYu Sato
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mahmoud SalamiFumitaka Kimura
Aug 24, 2004·Current Opinion in Neurobiology·Peter Heil
Nov 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nachum UlanovskyIsrael Nelken
Nov 5, 2005·Neuron·Michael R DeWeeseAnthony M Zador
Dec 22, 2005·Biological cybernetics·Simon StringerJ H Proske
Dec 28, 2005·Neural Computation·Eugene M Izhikevich
May 5, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jan SchnuppBashir Ahmed
Jan 18, 2007·The Journal of the Acoustical Society of America·Ray Meddis, Lowel P O'Mard
Feb 16, 2007·Hearing Research·Israel Nelken, Gal Chechik
Feb 5, 2008·IEEE Transactions on Neural Networks·E M Izhikevich
Apr 22, 2008·Neuroscience·P X Joris, P H Smith
Jun 18, 2009·Hearing Research·William S RhodeAlberto Recio-Spinoso
Sep 11, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Srivatsun Sadagopan, Xiaoqin Wang
Nov 10, 2009·The Journal of the Acoustical Society of America·Muhammad S A ZilanyLaurel H Carney
Aug 1, 2012·Frontiers in Computational Neuroscience·James M TromansSimon Stringer
Sep 21, 2013·Nature Reviews. Neuroscience·Jennifer K Bizley, Yale E Cohen
Feb 26, 2016·Nature Neuroscience·Sophie Denève, Christian K Machens

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