A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
J D CohenRandall C O'reilly

Abstract

In this chapter we consider the mechanisms involved in cognitive control-from both a computational and a neurobiological perspective- and how these might be impaired in schizophrenia. By 'control', we mean the ability of the cognitive system to flexibly adapt its behaviour to the demands of particular tasks, favouring the processing of task-relevant information over other sources of competing information, and mediating task-relevant behaviour over habitual, or otherwise prepotent responses. There is a large body of evidence to suggest that the prefrontal cortex (PFC) plays a critical role in cognitive control. In previous work, we have used a computational framework to understand and develop explicit models of this function of PFC, and its impairment in schizophrenia. This work has lead to the hypothesis that PFC houses a mechanism for representing and maintaining context information. We have demonstrated that this mechanism can account for the behavioural inhibition and active memory functions commonly ascribed to PFC, and for human performance in simple attention, language and memory tasks that draw upon these functions for cognitive control. Furthermore, we have used our models to simulate detailed patterns of cognitive defi...Continue Reading

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Citations

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