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A computational framework for detecting signatures of accelerated somatic evolution in cancer genomes

bioRxiv

Aug 16, 2017

Kyle S. SmithSubhajyoti De

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Abstract

By accumulation of somatic mutations, cancer genomes evolve, diverging away from the genome of the host. It remains unclear to what extent somatic evolutionary divergence is comparable across different regions of the cancer genome versus concentrated in specific genomic elements. We pre...read more

Mentioned in this Paper

Chromatin
Whole Genome Sequencing
Mutation Abnormality
Genome
Somatic Evolution
Biochemical Pathway
Oncogenes
Patterns
Cancer Promoting Genes
Genomic DNA
15
6
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  • A computational framework for detecting signatures of accelerated somatic evolution in cancer genomes

    bioRxiv

    Aug 16, 2017

    Kyle S. SmithSubhajyoti De

    PMID: 990177261

    DOI: 10.1101/177261

    Abstract

    By accumulation of somatic mutations, cancer genomes evolve, diverging away from the genome of the host. It remains unclear to what extent somatic evolutionary divergence is comparable across different regions of the cancer genome versus concentrated in specific genomic elements. We pre...read more

    Mentioned in this Paper

    Chromatin
    Whole Genome Sequencing
    Mutation Abnormality
    Genome
    Somatic Evolution
    15
    6

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