A computational model of epithelial solute and water transport along a human nephron

PLoS Computational Biology
Anita T Layton, Harold E Layton

Abstract

We have developed the first computational model of solute and water transport from Bowman space to the papillary tip of the nephron of a human kidney. The nephron is represented as a tubule lined by a layer of epithelial cells, with apical and basolateral transporters that vary according to cell type. The model is formulated for steady state, and consists of a large system of coupled ordinary differential equations and algebraic equations. Model solution describes luminal fluid flow, hydrostatic pressure, luminal fluid solute concentrations, cytosolic solute concentrations, epithelial membrane potential, and transcellular and paracellular fluxes. We found that if we assume that the transporter density and permeabilities are taken to be the same between the human and rat nephrons (with the exception of a glucose transporter along the proximal tubule and the H+-pump along the collecting duct), the model yields segmental deliveries and urinary excretion of volume and key solutes that are consistent with human data. The model predicted that the human nephron exhibits glomerulotubular balance, such that proximal tubular Na+ reabsorption varies proportionally to the single-nephron glomerular filtration rate. To simulate the action of...Continue Reading

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Citations

Mar 16, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Sameed AhmedAnita T Layton
Feb 6, 2020·Acta Physiologica·Bruce S GardinerRoger G Evans
Oct 1, 2019·American Journal of Physiology. Renal Physiology·Rui HuAnita T Layton
Nov 5, 2019·Journal of the American Society of Nephrology : JASN·Megan L GliozziOra A Weisz
May 14, 2020·American Journal of Physiology. Cell Physiology·Joshua L ReinLisa M Satlin
Feb 20, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Julia StabinskaHans-Jörg Wittsack
Jun 3, 2021·International Journal of Molecular Sciences·Rui Hu, Anita Layton

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