A computational model of flow and species transport in the mesangium

American Journal of Physiology. Renal Physiology
Sarah E HuntVictor H Barocas

Abstract

A variety of macromolecules accumulate in the glomerular mesangium in many different diseases, but the physics of the transport of these molecules within the mesangial matrix has not been extensively studied. We present a computational model of convection and diffusion within the porous mesangial matrix and apply this model to the specific instance of immunoglobulin A (IgA) transport in IgA nephropathy. We examine the influence of physiological factors including glomerular basement membrane (GBM) thickness and mesangial matrix density on the total accumulation of IgA. Our results suggest that IgA accumulation can be understood by relating convection and diffusion, thus demonstrating the importance of intrinsic glomerular factors.

References

Oct 30, 1975·Virchows Archiv. A, Pathological Anatomy and Histology·H Wehner, B Majorek
Mar 1, 1975·Circulation Research·B D MyersB M Brenner
Feb 1, 1976·The Journal of Clinical Investigation·R C BlantzB J Tucker
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S R Chary, R K Jain
Nov 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A F Michael, Y Kim
Oct 1, 1987·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D Schlondorff
Oct 1, 1987·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J R Levick
Nov 1, 1972·The American Journal of Physiology·W M DeenB M Brenner
Oct 1, 1972·The American Journal of Physiology·J B CoelhoS E Bradley
Feb 1, 1980·Kidney International·A F MichaelS M Mauer
Aug 1, 1994·Kidney International·F G CosioD D Sedmak
Jan 1, 1994·The American Journal of Physiology·M C Drumond, W M Deen
Jan 1, 1993·The American Journal of Physiology·R C BlantzC B Wilson
May 1, 1997·Current Opinion in Nephrology and Hypertension·V S KamannaM A Kirschenbaum
Jul 23, 1998·Physiological Reviews·J D Stockand, S C Sansom
Jun 11, 1999·The American Journal of Physiology·A EdwardsW M Deen
Jul 21, 1999·Kidney International. Supplement·Y NishidaN Yorioka
Nov 7, 2000·British Journal of Anaesthesia·J P NicholsonG R Park
Aug 31, 2002·Biophysical Journal·Saroja RamanujanRakesh K Jain
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Marie-Thérèse LinossierFrançois Berthoux
Jun 9, 2006·The New England Journal of Medicine·Lesley A StevensAndrew S Levey
Nov 10, 2006·Journal of the American Society of Nephrology : JASN·Laura M Dember
Apr 27, 2007·Annual Review of Biomedical Engineering·Melody A Swartz, Mark E Fleury
Jul 12, 2007·The Journal of Membrane Biology·Jian YaoMasanori Kitamura
Aug 24, 2007·American Journal of Physiology. Renal Physiology·Christopher R NealDavid O Bates
Jan 29, 2008·Seminars in Nephrology·Ivan C MouraRenato C Monteiro
Apr 9, 2008·Physiological Reviews·Börje HaraldssonWilliam M Deen
May 28, 2009·Journal of the American Society of Nephrology : JASN·Detlef Schlöndorff, Bernhard Banas
Nov 20, 2009·Kidney International·Rosanna CoppoRichard J Glassock
Jan 22, 2011·Contributions to Nephrology·Guillermo A HerreraJiamin Teng
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chung Hang J ChoiMark E Davis
Mar 21, 2012·Nature Reviews. Nephrology·Kar Neng Lai
Mar 28, 2012·The Journal of Experimental Medicine·Laureline BerthelotRenato C Monteiro
Dec 14, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohamed R Daha, Cees van Kooten
Jun 21, 2013·The New England Journal of Medicine·Robert J Wyatt, Bruce A Julian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
P Kincaid-Smith, K Nicholls
Contributions to Nephrology
G Richet
British Medical Journal
P Kincaid-Smith
Contributions to Nephrology
J MustonenH Helin
© 2021 Meta ULC. All rights reserved