A computational model of human granulopoiesis to simulate the hematotoxic effects of multicycle polychemotherapy.

Blood
Christoph EngelMarkus Loeffler

Abstract

Moderate intensification of conventional multicycle chemotherapy has recently been shown to improve treatment results in malignant lymphomas and might prove to be beneficial also in other malignancies. However, the feasibility of such regimens is mainly limited by their granulopoietic toxicity. To identify and quantify the basic cell kinetic mechanisms of damage and stimulation caused by cytotoxic drugs and recombinant human granulocyte colony-stimulating factor (rhG-CSF), respectively, we developed a mathematical model of human granulopoiesis that allows simulation of leukocyte concentration profiles under 10 different multicycle polychemotherapy regimens with varying drug composition, dosage, and scheduling, including rhG-CSF assistance. Clinical data on leukocyte profiles were obtained from large numbers of patients treated within several multicenter trials. Simulation studies show that the leukocyte profiles of all regimens can be appropriately fitted using one single set of assumptions and parameters for the cell kinetic effects of cytotoxic drugs and rhG-CSF. Furthermore, the model can be used to explain the interindividual heterogeneity of hematotoxicity by a differential chemosensitivity, which might be useful in drug s...Continue Reading

References

Jan 1, 1992·Archives of Toxicology·S SchedingH E Wichmann
Sep 1, 1990·Cell and Tissue Kinetics·S SchmitzH E Wichmann
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B I LordT M Dexter
Jul 28, 1986·The American Journal of Medicine·G P Bodey
Feb 1, 1972·Journal of Cellular Physiology·H D Preisler, E S Henderson
Nov 28, 1974·The New England Journal of Medicine·D C DaleS M Wolff
Sep 14, 1984·JAMA : the Journal of the American Medical Association·F P LiR Gelman
May 1, 1995·British Journal of Haematology·S SchmitzV Diehl
May 1, 1995·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M GorschlüterH Tesch
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V Trillet-LenoirD Tomita
Jan 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D HasencleverV Diehl
May 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M SieberUNKNOWN German Hodgkin's Lymphoma Study Group
Jun 11, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A WunderlichUNKNOWN German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL)
Jun 13, 2003·The New England Journal of Medicine·Volker DiehlUNKNOWN German Hodgkin's Lymphoma Study Group
Aug 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J K DoorduijnP Sonneveld
Apr 6, 2004·Annals of Hematology·O BrosteanuUNKNOWN German Hodgkin's Lymphoma Study Group

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Citations

Jul 31, 2013·Annals of Hematology·S ZeynalovaUNKNOWN German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL)
Dec 23, 2004·Journal of Mathematical Biology·M ScholzM Loeffler
Mar 5, 2008·Journal of Mathematical Biology·Catherine Foley, Michael C Mackey
Jun 27, 2013·Pharmaceutical Research·Mélanie L PastorDidier Concordet
Jul 31, 2012·Pathology Oncology Research : POR·Dan WuYi Xiao
Aug 10, 2012·Journal of Biological Dynamics·Shinji Nakaoka, Kazuyuki Aihara
Feb 5, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C ZwickUNKNOWN German High-Grade Non-Hodgkin Lymphoma Study Group
Jun 7, 2006·Current Opinion in Hematology·Ingo Roeder
Aug 1, 2012·Theoretical Biology & Medical Modelling·Markus ScholzMarkus Loeffler
Jun 3, 2014·Theoretical Biology & Medical Modelling·Sibylle SchirmMarkus Scholz
Dec 30, 2014·BMC Systems Biology·Sibylle SchirmMarkus Scholz
Sep 18, 2012·Journal of Theoretical Biology·Grace BrooksMichael C Mackey
Jan 20, 2010·Journal of Theoretical Biology·Markus ScholzMarkus Loeffler
Feb 21, 2006·British Journal of Haematology·Markus ScholzUNKNOWN German High Grade Non-Hodgkin Lymphoma Study Group (DSHNHL)
Dec 6, 2012·Radiation Research·Ann M FareseThomas J MacVittie
Nov 1, 2011·Journal of Theoretical Biology·Changjing ZhugeMichael C Mackey
Jun 27, 2018·PloS One·Nicolas Houy, François Le Grand
Apr 19, 2017·CPT: Pharmacometrics & Systems Pharmacology·M Craig
Nov 6, 2017·Journal of Cancer Research and Clinical Oncology·Sibylle SchirmMarkus Scholz
Aug 27, 2017·BMC Systems Biology·Joyatee M SarkerAnn E Rundell
Apr 24, 2021·IScience·Nathaniel Vincent Mon PèreDavid Dingli

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