A computational model of the [Formula: see text] transients and influence of buffering in guinea pig urinary bladder smooth muscle cells

Journal of Bioinformatics and Computational Biology
Vijay Dave, Rohit Manchanda

Abstract

Many cellular events including electrical activity and muscle contraction are regulated and coordinated by intracellular [Formula: see text] concentration ([[Formula: see text]][Formula: see text]. In detrusor smooth muscle (DSM) cells, [[Formula: see text]]i is normally maintained at very low levels and rises transiently during signalling processes as a result of (i) influx from the extracellular space (mainly via L-type and T-type [Formula: see text] channels) and (ii) [Formula: see text] release from sarcoplasmic reticulum (SR) into the cytoplasm. Intracellular [Formula: see text] buffers, both fixed and diffusible, play a vital role in shaping the radial distribution of free [Formula: see text]. Our aim, in the work presented here, is to develop a mathematical model of [Formula: see text] buffering and diffusion and to generate [Formula: see text] transient in guinea pig DSM cells. The [Formula: see text] transient is generated using inward [Formula: see text] current that arises following voltage clamp and mediated by L-type and T-type [Formula: see text] channels. [Formula: see text] transient is obtained for different radial locations (or shells) of the DSM cytosol. This modeling study explores the levels of [[Formula: s...Continue Reading

References

Feb 1, 1990·Biophysical Journal·F Sala, A Hernández-Cruz
Dec 1, 1985·Pflügers Archiv : European journal of physiology·U Klöckner, G Isenberg
Mar 1, 1972·The Journal of Cell Biology·C E DevineA P Somlyo
Jul 1, 1994·Biophysical Journal·G J Kargacin
Aug 22, 2003·BJU International·G P SuiC H Fry
Jan 16, 2004·Trends in Pharmacological Sciences·Damon PoburkoCornelis van Breemen
Sep 24, 2005·American Journal of Physiology. Cell Physiology·Kozo MorimuraYuji Imaizumi
Nov 18, 2005·American Journal of Physiology. Cell Physiology·Li LiuRichard J Paul
Jul 31, 2007·Biochemical Pharmacology·Pedro J Gomez-PinillaPedro J Camello
Jan 21, 2010·Physiological Reviews·Susan Wray, Theodor Burdyga
Nov 17, 2012·Urology·Seham Mustafa

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