A computational study of the development of epithelial acini: I. Sufficient conditions for the formation of a hollow structure

Bulletin of Mathematical Biology
Katarzyna A Rejniak, Alexander R A Anderson

Abstract

Normal hollow epithelial acini are 3-dimensional culture structures that resemble the architecture and functions of normal breast glands and lobules. This experimental model enables in vitro investigations of genotypic and molecular abnormalities associated with epithelial cancers. However, the way in which the acinar structure is formed is not yet completely understood. Gaining more information about consecutive stages of acini development-starting from a single cell that gives rise to a cluster of randomly oriented cells, followed by cell differentiation that leads to a layer of polarised cells enclosing the hollow lumen-will provide insight into the transformations of eukaryotic cells that are necessary for their successful arrangement into an epithelium. In this paper, we introduce a two-dimensional single-cell-based model representing the cross section of a typical acinus. Using this model, we investigate mechanisms that lead to the unpolarised cell growth, cell polarisation, stabilisation of the acinar structure and maintenance of the hollow lumen and discuss the sufficient conditions for each stage of acinar formation. In the follow-up paper (Rejniak and Anderson, A computational study of the development of epithelial ac...Continue Reading

References

Jan 1, 1991·International Review of Experimental Pathology·M J Arends, A H Wyllie
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·D J Ferguson
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·D J Ferguson, T J Anderson
Mar 25, 1999·Journal of Theoretical Biology·R Dillon, H G Othmer
Jul 3, 2002·Nature Reviews. Molecular Cell Biology·Lucy Erin O'BrienKeith E Mostov
Jun 12, 2003·Methods : a Companion to Methods in Enzymology·Jayanta DebnathJoan S Brugge
Feb 12, 2004·Bulletin of Mathematical Biology·Katarzyna A RejniakLisa J Fauci
Mar 23, 2005·Mathematical Medicine and Biology : a Journal of the IMA·Alexander R A Anderson
Apr 20, 2005·Journal of Mammary Gland Biology and Neoplasia·Kenna R Mills ShawJoan S Brugge
Sep 9, 2005·Nature Reviews. Cancer·Jayanta Debnath, Joan S Brugge
Apr 11, 2008·Bulletin of Mathematical Biology·Katarzyna A Rejniak, Alexander R A Anderson
Jul 1, 2005·Mathematical Biosciences and Engineering : MBE·Katarzyna A Rejniak

❮ Previous
Next ❯

Citations

Oct 8, 2008·Journal of Mathematical Biology·Alexander R A AndersonVito Quaranta
Oct 12, 2011·Journal of Mathematical Biology·Yibao LiJunseok Kim
Apr 11, 2008·Bulletin of Mathematical Biology·Katarzyna A Rejniak, Alexander R A Anderson
Nov 26, 2010·Mathematical Medicine and Biology : a Journal of the IMA·Katarzyna A RejniakAlexander R A Anderson
Nov 6, 2009·Cancer Research·Alexander R A AndersonAlissa M Weaver
Sep 25, 2010·PLoS Computational Biology·Katarzyna A RejniakAlexander R A Anderson
Apr 15, 2011·PLoS Computational Biology·Jesse A EngelbergC Anthony Hunt
Sep 22, 2010·PloS One·Yousef JamaliMohammad R K Mofrad
Mar 5, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Jonathan TangSylvain V Costes
May 17, 2011·Seminars in Cancer Biology·K SaetzlerA M Soto
Mar 23, 2011·Progress in Biophysics and Molecular Biology·Philip GerleeAlexander R A Anderson
Nov 11, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Katarzyna A Rejniak, Alexander R A Anderson
Aug 20, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Haralampos HatzikirouVittorio Cristini
Sep 8, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Chun-Chao WangKevin A Janes
Feb 11, 2015·Bio Systems·Osvaldo Chara, Lutz Brusch
May 6, 2014·Soft Matter·Anna MkrtchyanMikko Karttunen
Sep 3, 2010·Nonlinearity·J S LowengrubV Cristini
Mar 29, 2019·PLoS Computational Biology·Chad M GlenEberhard O Voit
Jan 26, 2018·Journal of the Royal Society, Interface·Aleksandra KarolakKatarzyna A Rejniak
Nov 22, 2019·Biomechanics and Modeling in Mechanobiology·Paul Van LiedekerkeDirk Drasdo
Dec 12, 2018·Journal of Theoretical Biology·Ying Chen, John S Lowengrub

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.