A computational study of the interaction between coronary blood flow and myocardial mechanics

Physiological Measurement
Nicolas P Smith

Abstract

An anatomically based computational model of coronary blood flow, coupled to cardiac mechanics, is verified with experimental data and used to investigate the mechanisms by which myocardial contraction inhibits coronary blood flow. From finite deformation mechanics solutions the regional variation in intramyocardial pressure (IMP) exerted on coronary vessels embedded in the ventricular wall is calculated. This pressure is then coupled to a haemodymanic model of vascular blood flow to predict the spatial-temporal characteristics of perfusion throughout the myocardium. The calculated IMP is shown to vary approximately linearly between ventricular pressure at the endocardium and atmospheric pressure at the epicardium through the diastolic loading and isovolumic contraction phases. During the ejection and isovolumic relaxation phases IMP values rise slightly above ventricular pressure. The average radius of small arterial vessels embedded in the myocardium decreases during isovolumic contraction (18% at left ventricular endocardium) before increasing during ejection (10% at left ventricular endocardium) due to a rise in inflow pressure. Embedded venous vessels show a reduction in radius through both phases of contraction (35% at le...Continue Reading

Citations

May 9, 2012·Annals of Biomedical Engineering·Jack Lee, Nicolas P Smith
Dec 15, 2012·Journal of Biomechanics·Jeroen P H M van den WijngaardMaria Siebes
Jun 19, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Jos SpaanMaria Siebes
Dec 8, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Dotan AlgranatiYoram Lanir
Oct 16, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Paul D JöbsisRobert S Balaban
Sep 7, 2012·Computational and Mathematical Methods in Medicine·Dongdong DengLing Xia
Nov 3, 2010·Progress in Biophysics and Molecular Biology·Sarah L WatersFrans N van de Vosse
Sep 25, 2015·Annals of Biomedical Engineering·Pablo LamataNic Smith
Nov 18, 2009·Progress in Biophysics and Molecular Biology·D A NordslettenN P Smith
Jan 25, 2013·International Journal for Numerical Methods in Biomedical Engineering·C MichlerN P Smith
Jul 1, 2015·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Matthew D SinclairNicolas P Smith
Sep 1, 2014·Journal of Biomechanics·Maya KhaliféDima Rodríguez
Feb 15, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Claudio De LazzariDanilo Neglia
Jun 28, 2018·International Journal for Numerical Methods in Biomedical Engineering·Xinyang GeFuyou Liang
Jul 22, 2018·Journal of Biomechanical Engineering·Daphne MezaWei Yin
Dec 3, 2008·Journal of Biomechanical Engineering·J JacobsY Lanir
Oct 4, 2006·Physiological Reviews·Nico WesterhofPieter Sipkema
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Mar 7, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Ravi NamaniGhassan S Kassab
May 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Jonathan P Mynard, Joseph J Smolich
Mar 6, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Christopher J ArthursC Alberto Figueroa
Dec 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Lei FanLik Chuan Lee
Nov 14, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Patricia E McCallinhartAaron J Trask
Feb 10, 2021·International Journal for Numerical Methods in Biomedical Engineering·Scott I Heath RichardsonXiaoyu Luo

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