A computational study of the interdependencies between neuronal impulse pattern, noise effects and synchronization

Journal of Physiology, Paris
S PostnovaH A Braun

Abstract

Alterations of individual neurons dynamics and associated changes of the activity pattern, especially the transition from tonic firing (single-spikes) to bursts discharges (impulse groups), play an important role for neuronal information processing and synchronization in many physiological processes (sensory encoding, information binding, hormone release, sleep-wake cycles) as well as in disease (Parkinson, epilepsy). We have used Hodgkin-Huxley-type model neurons with subthreshold oscillations to examine the impact of noise on neuronal encoding and thereby have seen significant differences depending on noise implementation as well as on the neuron's dynamic state. The importance of the individual neurons' dynamics is further elucidated by simulation studies with electrotonically coupled model neurons which revealed mutual interdependencies between the alterations of the network's coupling strength and neurons' activity patterns with regard to synchronization. Remarkably, a pacemaker-like activity pattern which revealed to be much more noise sensitive than the bursting patterns also requires much higher coupling strengths for synchronization. This seemingly simple pattern is obviously governed by more complex dynamics than expe...Continue Reading

References

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Jan 1, 1995·Annual Review of Neuroscience·W Singer, C M Gray
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May 23, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Martin Tobias Huber, Hans Albert Braun
May 7, 2008·Mathematical Biosciences·Christian FinkeHans Albert Braun
Apr 1, 2007·Journal of Biological Physics·Svetlana PostnovaHans A Braun

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Citations

Feb 2, 2013·Cognitive Neurodynamics·Jingyi QuJianting Cao
Mar 14, 2014·Cognitive Neurodynamics·Jingyi QuYing Du
Jan 10, 2012·Chaos·Christian FinkeUlrike Feudel
Jun 14, 2012·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Catherine Stamoulis, Bernard S Chang
Mar 15, 2015·Frontiers in Neurology·Siamak SorooshyariLuis de Lecea
Nov 6, 2018·Chaos·Noah Holmgren HopkinsSvetlana Postnova

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