PMID: 11923188Mar 30, 2002Paper

A computational system for simulating and analyzing arrays of biological and artificial chemical sensors

Chemical Senses
T K AlkasabJ S Kauer

Abstract

We have designed an approach for modeling olfactory pathways by which one can explore how the properties of individual receptors affect the information coding capacity of an entire system. The effect of receptor tuning breadth on system performance was explored explicitly. We presented model sensory arrays with sets of stimuli randomly and uniformly distributed in an "olfactory space". Arrays of uniformly sized model receptors responding to 25-35% of the stimuli gave the best performance as measured by the ability to capture the most information about the stimulus set. Arrays of variably sized model receptors that were both more broadly and more narrowly tuned than this optimum could, however, perform better than uniform arrays. This method and the results obtained using it suggest a framework for considering the growing body of evidence on the functional properties of individual olfactory receptor and relay neurons from a systems coding perspective.

Citations

May 17, 2002·Nature·John S Kauer
Nov 21, 2008·Neural Computation·Mehmet K MuezzinogluMikhail I Rabinovich
Jan 26, 2006·BMC Neuroscience·Thomas A Cleland, Praveen Sethupathy
Jan 25, 2008·PLoS Biology·Joel WhiteJohn S Kauer
Jan 21, 2014·Analytica Chimica Acta·Jordi FonollosaSantiago Marco
Aug 22, 2014·Journal of the Royal Society, Interface·Javier CerveraSalvador Mafe
Apr 23, 2008·The Analyst·Richard G SmithStephen Nicklin
Jul 22, 2006·IEEE Transactions on Neural Networks·Baranidharan RamanRicardo Gutierrez-Osuna
Jun 3, 2004·The Journal of Comparative Neurology·James E MarchandJohn S Kauer
Nov 3, 2005·Protein Engineering, Design & Selection : PEDS·Addison D Ault, James R Broach
Nov 4, 2005·Chemical Senses·Thomas A Cleland, Christiane Linster
Sep 1, 2008·Journal of Breath Research·A Gelperin, A T C Johnson
Jul 10, 2010·Analytical Chemistry·Ariya AkthakulJoel White
Mar 14, 2017·Journal of Agricultural and Food Chemistry·Madeleine M RochelleTerry E Acree
May 28, 2019·ACS Sensors·Jenna A Gustafson, Christopher E Wilmer
Jan 18, 2008·Chemical Reviews·Andreas Hierlemann, Ricardo Gutierrez-Osuna

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