A computer-aided design tool for biomedical OBT sensor tuning in cell-culture assays.

Computer Methods and Programs in Biomedicine
P PerezAlberto Yúfera

Abstract

The biomedical engineering must frequently develop sensor designs by including information from performance of bio-samples (cell cultures or tissues), technical specifications of transducers, and constrains from electronic circuits. A computer program for real-time cell culture monitoring system design is developed; analyzing, modelling and integrating into the program design flow the electrodes, cell culture and test circuit's influences. The computer tool, first, generates an equivalent electric circuit model for the cell-electrode bio-systems based on the area covered by cells, which also considers the cell culture dynamics. Second, proposes an Oscillation Based Test (OBT) parameterized circuit, for Electrical Cell-Substrate Sensing (ECIS) measurements of the cell culture system bioimpedance. Third, simulates electrically the full system to define the best system parameter values for the sensor. Reported experimental results are based on commercial gold electrodes and the AA8 cell line. Characteristics of the cell lines, as time-division or cell size, are incorporated into the program design flow, showing that for a given assay, the optimal OBT circuit parameters can be selected with the help of the computer tool. The electr...Continue Reading

References

Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·I Giaever, C R Keese
Jan 1, 1957·Advances in Biological and Medical Physics·H P SCHWAN
Jan 30, 2018·IEEE Transactions on Biomedical Circuits and Systems·Milad ZamaniWouter A Serdijn
Jun 13, 2018·Scientific Reports·Pablo PérezAlberto Yúfera

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