PMID: 8590606Jul 1, 1995Paper

A computer modeling postulated mechanism for angiotensin II receptor activation

Journal of Protein Chemistry
M P JosephH A Scheraga

Abstract

The angiotensin II receptor of the AT1-type has been modeled starting from the experimentally determined three-dimensional structure of bacteriorhodopsin as the template. Intermediate 3D structures of rhodopsin and beta 2-adrenergic receptors were built because no direct sequence alignment is possible between the AT1 receptor and bacteriorhodopsin. Docking calculations were carried out on the complex of the modeled receptor with AII, and the results were used to analyze the binding possibilities of DuP753-type antagonistic non-peptide ligands. We confirm that the positively charged Lys199 on helix 5 is crucial for ligand binding, as in our model; the charged side chain of this amino acid interacts strongly with the C-terminal carboxyl group of peptide agonists or with the acidic group at the 2'-position of the biphenyl moiety of DuP753-type antagonists. Several other receptor residues which are implicated in the binding of ligands and the activation of receptor by agonists are identified, and their functional role is discussed. Therefore, a plausible mechanism of receptor activation is proposed. The three-dimensional docking model integrates most of the available experimental observations and helps to plan pertinent site-direct...Continue Reading

References

May 25, 1977·Journal of Molecular Biology·F C BernsteinM Tasumi
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K C ChouH A Scheraga
Sep 30, 1992·Biochemical and Biophysical Research Communications·Y YamanoT Inagami
Dec 15, 1992·Biochemical and Biophysical Research Communications·K OhyamaT Inagami
Sep 1, 1992·Trends in Pharmacological Sciences·U M SteckelingsT Unger
Feb 28, 1992·Biochemical and Biophysical Research Communications·H FurutaT Inagami
Mar 31, 1992·Biochemical and Biophysical Research Communications·S S KakarJ D Neill
Apr 30, 1992·Biochemical and Biophysical Research Communications·T S EltonS Oparil
May 29, 1992·Biochemical and Biophysical Research Communications·H SasamuraV J Dzau
Jul 5, 1992·Journal of Molecular Biology·J B MitchellS L Price
Mar 29, 1991·Biochemical and Biophysical Research Communications·D N WoolfsonD H Williams
Jan 5, 1992·Journal of Molecular Biology·P C LyuN R Kallenbach
Mar 20, 1991·Journal of Molecular Biology·L SerranoA R Fersht
Apr 5, 1991·Journal of Molecular Biology·G von Heijne
May 31, 1991·Biochemical and Biophysical Research Communications·N IwaiT Inagami
Dec 20, 1990·Journal of Molecular Biology·A HorovitzA R Fersht
Jan 1, 1990·Biopolymers·R Sankararamakrishnan, S Vishveshwara
Jan 1, 1990·Biopolymers·C M DeberG A Woolley
Jun 20, 1990·Journal of Molecular Biology·R HendersonK H Downing
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S SheriffD R Davies
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T P SakmarH G Khorana
Jun 20, 1988·Journal of Molecular Biology·M Levitt, M F Perutz
Nov 16, 1987·FEBS Letters·J SinghS F Campbell
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J Nathans, D S Hogness
Oct 28, 1994·Journal of Molecular Biology·M CserzöB Maigret
Jan 1, 1994·Annual Review of Biochemistry·C D StraderR A Dixon
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·H T SchambyeT W Schwartz
Jan 1, 1993·Trends in Pharmacological Sciences·M F HibertA Bruinvels
Oct 1, 1993·Protein Science : a Publication of the Protein Society·B M Huyghues-DespointesR L Baldwin
Dec 15, 1993·Biochemical and Biophysical Research Communications·A T ChiuP Benfield
Jan 1, 1993·Journal of Neurochemistry·R J Summers, L R McMartin

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Citations

Feb 4, 2011·European Biophysics Journal : EBJ·Julia PreuThomas Gutberlet
Jan 13, 2006·Journal of Molecular Modeling·Camelia Baleanu-Gogonea, Sadashiva Karnik
Jan 18, 1996·European Journal of Pharmacology·A JagerschmidtB P Roques
Dec 12, 2012·The Journal of Biological Chemistry·Jérôme CabanaPierre Lavigne
Aug 31, 2001·Biochemical and Biophysical Research Communications·G V Nikiforovich, G R Marshall
Dec 9, 2008·Molecular and Cellular Endocrinology·Christophe Petrel, Eric Clauser
Mar 12, 2004·Biochemical and Biophysical Research Communications·Ryuji KatoHiroyuki Honda
Oct 13, 2005·The Journal of Peptide Research : Official Journal of the American Peptide Society·G V NikiforovichG R Marshall
Aug 25, 2004·Proteins·Sharon ShachamOren M Becker
May 3, 2003·Journal of Peptide Science : an Official Publication of the European Peptide Society·Giuseppe NicastroAlberto Spisni
Dec 21, 2006·Chemical Biology & Drug Design·Gregory V NikiforovichKevin J Catt
Jan 27, 2004·Journal of Chemical Information and Computer Sciences·Prasanna A DatarEvans C Coutinho
Apr 26, 2012·Journal of Chemical Information and Modeling·Amit K GuptaAnil K Saxena
Mar 1, 2001·Journal of the Renin-angiotensin-aldosterone System : JRAAS·László HunyadyKevin J Catt
Jul 16, 2008·Applied Microbiology and Biotechnology·Yi-han LiuChen Gao
Apr 10, 2012·European Biophysics Journal : EBJ·David Jimenez-MoralesBob Eisenberg
Nov 9, 2010·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Romeu Cardoso Guimarães
Sep 1, 2019·Journal of Computational Chemistry·Alexey Aleksandrov
Apr 26, 1996·The Journal of Biological Chemistry·K BefortB L Kieffer
Dec 1, 1995·International Journal of Peptide and Protein Research·M P JosephH A Scheraga

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