PMID: 6166219Jul 1, 1981Paper

A computer program for determining Vmax from the uncalibrated left ventricular pressure signal and its first derivative

Angiology
M A Stefadouros, M J Williams

Abstract

A computer program was developed to simplify the conventional method for determining the maximal contractile element shortening velocity at zero load (Vmax) by analysis of pressure-velocity graphs during the isovolumic contraction period. From an uncalibrated left ventricular (LV) pressure signal and its first derivative (dP/dt), the graph relating developed LV pressure (Pd) to the corresponding instantaneous value of (dP/dt)/28 Pd was constructed by the computer. The segment of the graph that encompassed approximately the second half of the isovolumic contraction period, as determined by analysis of the dP/dt waveform, was then extrapolated to provide V'max on the ordinate. This V'max was compared with the conventional Vmax obtained from calibrated LV and aortic pressure signals. In 5 dogs both in the control state and during inotropic (epinephrine, propranolol) and noninotropic interventions (phenylephrine or dextran infusion), a high degree of correlation was found relating V'max and Vmax both derived by either linear (Vmax = 0.91 V'max + 0.14; r = 0.933; P less than 0.001) or exponential (Vmax = 0.99 V'max - 0.06; r = 0.959; P less than 0.001) extrapolation of the pressure-velocity graph to zero load. By use of this program...Continue Reading

References

Jan 1, 1972·Circulation Research·W W ParmleyE H Sonnenblick
Jan 1, 1971·Cardiovascular Research·N S NejadB Lown
Feb 1, 1969·Annals of Internal Medicine·E BraunwaldS E Epstein
Apr 1, 1969·The American Journal of Cardiology·E H SonnenblickC W Urschel
Apr 1, 1963·The American Journal of Physiology·E H SONNENBLICK, S E DOWNING

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