A computerized human reference brain for rCBF/SPET technetium-99m exametazime (HMPAO) investigation of elderly

Clinical Physiology and Functional Imaging
Karin Sparring BjörksténGöran Granerus

Abstract

Using the bull's eye approach, a reference brain from the single photon emission tomography (SPET) images of 10 subjects aged 62-81 years with excellent mental and physical health was constructed. SPET images were acquired twice, 1 week apart, using a single detector rotating gamma camera collecting 64 planar images over a 360 degrees orbit. The centre of each transaxial slice was first defined with an automatic edge detecting algorithm applied to an anterior-posterior and a side profile of the brain. Each slice was divided into 40 sectors. Maximum counts/pixel in each sector was picked. The 40 maximum count values from one transaxial slice were allowed to form a horizontal row in a new parametric image on the x-axis and slice number from the vertex to the basal parts of the brain on the y-axis. This new image was scaled to a 64 x 16 pixel matrix by interpolation, which meant a normalization of all studies to the same size. The parametric image in each subject was scaled with regard to intensity by a factor calculated by a normalization procedure using the least squares analysis. Mean and SD for each pixel were calculated, thereby constructing a "mean parametric image", and a "SD parametric image". These two images are meant to...Continue Reading

References

May 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G WaldemarO B Paulson
Mar 1, 1991·Clinical Nuclear Medicine·N D GreysonJ E Wilmot
Jan 1, 1989·The Journal of Neuropsychiatry and Clinical Neurosciences·R A O'ConnellL N King
Dec 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G RodriguezG Rosadini
Oct 1, 1994·Nuclear Medicine Communications·A ArligC Wikkelsö
Sep 6, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Durval C Costa
Apr 1, 1993·The Clinical Neuropsychologist·James R YoungjohnThomas H Crook

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.