A computerized multichannel platelet aggregometer system

Journal of Pharmacological Methods
D KuzaraC A Kohler

Abstract

Commercially available instrumentation for conducting platelet aggregation studies in clinical and research laboratories consists of one-, two-, or four-channel aggregometers used in conjunction with strip chart recorders. These instruments have limited utility in large-scale drug screening and evaluation of the mode of action of drugs or in the clinical diagnosis of platelet disorders. A new instrument, a computerized multichannel aggregometer system (CMPAS) has been developed to collect, display, and analyze platelet aggregation data. The system is comprised of a 24-channel Born-type aggregometer, interfaced to a Rockwell AIM-65 microcomputer through an analogue-to-digital converter and an Epson dot-matrix printer. Each channel is individually calibrated, and aggregation data can be collected on up to 24 different platelet-rich plasma samples simultaneously. Conversational programs written in BASIC prompt the user for the addition of agonists and inhibitors. The tracings for each channel are displayed simultaneously, and a program automatically analyzes the data to generate the following parameters: baseline optical density, maximum aggregation response, positive and negative slopes, time to peak aggregation, and percentage r...Continue Reading

References

Sep 1, 1984·Journal of Pharmacological Methods·C A Kohler, B J Zoltan
May 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·H K NielsenS E Husted
Jan 1, 1981·Vox Sanguinis·M A Packham, J F Mustard
Jan 1, 1981·Annals of Internal Medicine·S J Shattil, J S Bennett
Jan 1, 1982·Annual Review of Pharmacology and Toxicology·R N Saunders

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Citations

Aug 22, 2006·Analytical Biochemistry·N MoranD Kenny

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