A Concise Approach to N -Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yongxi LiangXun Sun

Abstract

An efficient approach to obtain functionalized rhodanines was developed through a base-assisted one-pot coupling and continuous cyclization of a primary amine, carbon disulfide, and methyl (2-chloroacetyl)carbamate. This conversion tolerates a broad range of functional groups and can be used to scale the preparation of N-substituted rhodanines in excellent yields.

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Methods Mentioned

BETA
X-ray
column chromatography

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