A concise synthesis and biological study of evodiamine and its analogues

Chemical Communications : Chem Comm
Jie-Dan DengZhen Wang

Abstract

Efficient access to evodiamine and its analogues is presented via Lewis acid catalysis. In this reaction, three chemical bonds and two heterocyclic-fused rings are constructed in one step. The reaction shows good functional group tolerance and atom economy, and various heteroatom-containing evodiamine analogues are obtained in moderate to excellent yields even on a gram scale. An anti-tumor study in vitro demonstrates compound 2b possesses potent efficacy against hepatoma cell line (IC50 = 5.7 μM).

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Citations

Oct 2, 2019·Organic & Biomolecular Chemistry·Yiting SuHaijun Chen
Nov 30, 2020·European Journal of Medicinal Chemistry·Shumeng MaZhen Wang
Nov 20, 2020·Journal of Experimental & Clinical Cancer Research : CR·Ze-Bo JiangElaine Lai-Han Leung
Aug 2, 2021·Bioorganic Chemistry·Zhuo WangYusheng Xie
Sep 4, 2021·European Journal of Medicinal Chemistry·Jiayun WangXin Chen

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Methods Mentioned

BETA
transgenic
fluorescence

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