PMID: 2496421Jan 1, 1989Paper

A concurrently available nondrug reinforcer prevents the acquisition or decreases the maintenance of cocaine-reinforced behavior

Psychopharmacology
M E CarrollS L Nygaard

Abstract

Lever-pressing responses of 55 rats were reinforced with IV-delivered cocaine (0.2 mg/kg) or saline under conditions of continuous access for 15 24-h sessions. The rats also responded on tongue-operated drinking devices for deliveries of a 3% (w/v) glucose + 0.125% (w/v) saccharin (G+S) solution or water. The effects of removing these substances on behavior maintained by G+S, water, cocaine, or saline were compared in 11 groups. Terminating cocaine access produced a decrease in G+S drinking and an increase in food and water intake. In contrast, a group of rats that did not initially self-administer G+S showed increases in G+S drinking when cocaine was removed, and G+S-maintained responding persisted when cocaine was reinstated. Substitution of water for G+S produced a nearly two-fold increase in cocaine-reinforced behavior but no change in IV-delivered saline self-administration in a control group. A group that did not initially self-administer cocaine increased its infusion rate to over 400 infusions per day as soon as G+S was replaced with water. The effect of presenting cocaine to a group that responded for G+S alone was to decrease G+S intake, but there was only a transient decrease in water intake in the control group. Lik...Continue Reading

References

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Citations

Jun 1, 1994·Psychopharmacology·M A Nader, D M Reboussin
Jan 1, 1993·Psychopharmacology·A MarkouG F Koob
Sep 1, 1995·Psychopharmacology·S D ComerM E Carroll
Dec 1, 1995·Psychopharmacology·E C DonnyC Brown
Jan 1, 1996·Psychopharmacology·S T HigginsW K Bickel
Jan 30, 2010·Psychopharmacology·Natalie E ZlebnikMarilyn E Carroll
Jan 1, 1989·Life Sciences·M E CarrollR M Keenan
Dec 1, 1988·Pharmacology, Biochemistry, and Behavior·M E CarrollL H Brauer
Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·J P Zacny, H de Wit
Nov 1, 1990·Pharmacology, Biochemistry, and Behavior·M E CarrollR Kragh
Jan 1, 1990·Pharmacology, Biochemistry, and Behavior·M E CarrollR Kragh
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·L H EpsteinJ Rodefer
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·G R KingE H Ellinwood
Dec 1, 1994·Pharmacology, Biochemistry, and Behavior·G R KingE H Ellinwood
Apr 1, 1996·Pharmacology, Biochemistry, and Behavior·E GahtanM E Carroll
May 1, 1992·Alcohol·B A Gosnell, D D Krahn
Jun 4, 2005·Pharmacology, Biochemistry, and Behavior·Zuzana JustinovaGianluigi Tanda
Jul 16, 2002·Physiology & Behavior·A E KelleyM Zhang
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·K BrebnerD C Roberts
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Kelly P CosgroveMarilyn E Carroll
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Suzette M EvansRichard W Foltin
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·S T Higgins

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