PMID: 9421457Jan 8, 1998Paper

A concussive-like brain injury model in mice (II): selective neuronal loss in the cortex and hippocampus

Journal of Neurotrauma
Y P TangT Nabeshima

Abstract

A novel concussive-like brain injury (CLBI) model characterized by transient neurobehavioral depression, short duration of brain edema, and long-lasting memory deficits has been reported in our companion paper. This was achieved by dropping a 21-g weight from a height of 25 cm onto the head of a mouse. In the present study, we examined the histopathological changes in this model. Male ddY mice were subjected to either the trauma or sham injury. Gross pathological examination of the brain 1 h posttrauma did not demonstrate subdural, subarachnoid, intraventricular, periventricular, and intraparenchymatous hemorrhage, focal lesions or contusions. Microscopic examination 24 h posttrauma with Nissl staining (cresyl violet), however, revealed a selective bilateral neuronal cell loss in the cerebral cortex and hippocampus but not in the regions of the thalamus, cerebellum, and brain stem. The characteristics of neuronal cell loss in the cortex suggested that this pathology was related in part, to the head impact dynamics, since the cell loss was noted in the central portion of the supraventricular cerebral cortex (p < 0.001), the site of the weight impact, gradually decreasing peripheral to this site, and disappearing in the areas rem...Continue Reading

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Citations

Sep 5, 2002·Ultrasound in Medicine & Biology·Helmut L LaurerKathryn E Saatman
Dec 28, 2007·Journal of Neurotrauma·Désirée Griesemer, Angelika M Mautes
Aug 23, 2007·Journal of Neurotrauma·Ronald J FijalkowskiThomas A Gennarelli
Dec 14, 2011·Journal of Neurotrauma·Sharon OhayonAlexander Zlotnik
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Nov 13, 2001·Journal of Neurosurgery·H L LaurerT K McIntosh
Jul 30, 2014·Life Sciences· NehaNirmal Singh
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Aug 27, 2021·Neuroscience and Biobehavioral Reviews·Matthieu FaillotSuhan Senova

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