Apr 29, 2020

Males that silence their father's genes: genomic imprinting of a complete haploid genome

BioRxiv : the Preprint Server for Biology
Andrés G. de la FiliaL. Ross

Abstract

Genetic conflict is considered a key driver in the evolution of new reproductive and sex determining systems. In particular, reproductive strategies with non-Mendelian inheritance, where parents do not contribute equally to the genetic makeup of their offspring. One of the most extraordinary examples of non-Mendelian inheritance is paternal genome elimination (PGE), a form of haplodiploidy which has evolved repeatedly across arthropods. Under PGE, males are diploid but only transmit maternally-inherited chromosomes to their offspring, while the paternal homologues are excluded from sperm. This asymmetric inheritance is thought to have evolved through an evolutionary arms race between paternal and maternal genomes over transmission to future generations. In several clades with PGE, such as the mealybugs (Hemiptera: Pseudococcidae), paternal chromosomes are not just eliminated from sperm, but also heterochromatinised early in development and thought to remain inactive. Such paternal genome silencing could alleviate genetic conflict between paternal alleles over transmission. However, it is unclear if paternal chromosomes are indeed genetically inert in both soma and germline. Here, we present a parent-of-origin allele-specific tr...Continue Reading

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Mentioned in this Paper

Genetic Drift
Likelihood Functions
Sample Fixation
Ancient DNA
Alleles
Fixation - Action
Orientation (spatial)
Population Group
Landscapes
DNA

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