PMID: 15220684Jun 29, 2004Paper

A confirmatory report for the close interaction of Helicobacter pylori with gastric epithelial MUC5AC expression

Journal of Clinical Gastroenterology
Belma KocerAtilla Soran

Abstract

Helicobacter pylori (H. pylori) infection is associated with the development of gastritis and peptic ulcer and is presumed to be a risk factor for low-grade B-cell lymphoma and gastric cancer. H. pylori also causes critical alterations in gastric mucin structure. Our aim was to determine the effect of H. pylori on MUC1, MUC2, and MUC5AC expression. Thirty H. pylori-positive and 15 H. pylori-negative antral gastric endoscopic biopsy specimens were evaluated for MUC1, MUC2, and MUC5AC expression with immunohistochemical staining. From the same specimens, we scrutinized the presence of H. pylori infection by hematoxylin and eosin and immunohistochemical staining. In H. pylori infected patients, the expression of MUC5AC was found to be localized to the cells in the superficial epithelium and upper parts of the gastric glands. The number of MUC5AC-expressing cells and the staining intensity of MUC5AC were shown to decrease in patients with H. pylori infection. Histopathology and immunostaining patterns of gastric mucins implied that H. pylori was physically associated with extracellular MUC5AC and MUC5AC-producing cells. H. pylori infection does not significantly affect staining intensity and patterns of MUC1 and MUC2 expressions. M...Continue Reading

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Citations

Jul 5, 2007·Clinical and Experimental Medicine·I RadziejewskaA Gindzieński
Oct 19, 2010·Clinical and Experimental Medicine·Iwona RadziejewskaEwa Stefańska
May 25, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Michaël PerraisIsabelle Van Seuningen
Aug 6, 2013·Clinics and Research in Hepatology and Gastroenterology·Ding ShiXing-Jun Yan
Feb 3, 2015·Journal of Cellular Physiology·Maria De FalcoAntonio De Luca
Dec 22, 2007·Journal of Clinical Gastroenterology·Hyung Min KangIn Sung Song
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Cheng-Jiang ZhouYan-Bin Jia
Jun 1, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Ling HuWeijing Chen
Aug 27, 2015·World Journal of Gastroenterology : WJG·Yaron Niv
Jan 22, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Cheng-Jiang ZhouYan-Bin Jia

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