A conformational polymorphic transition in the high-temperature epsilon-form of chlorpropamide on cooling: a new epsilon'-form

Acta Crystallographica. Section B, Structural Science
Tatiana N DrebushchakElena V Boldyreva

Abstract

Structural changes in the high-temperature -polymorph of chlorpropamide, 4-chloro-N-(propylaminocarbonyl)benzenesulfonamide, C(10)H(13)ClN(2)O(3)S, on cooling down to 100 K and on reverse heating were followed by single-crystal X-ray diffraction. At temperatures below 200 K the phase transition into a new polymorph (termed the epsilon'-form) has been observed for the first time. The polymorphic transition preserves the space group Pna2(1), is reversible and is accompanied by discontinuous changes in the cell volume and parameters, resulting from changes in molecular conformation. As shown by IR spectroscopy and X-ray powder diffraction, the phase transition in a powder sample is inhomogeneous throughout the bulk, and the two phases co-exist in a wide temperature range. The cell parameters and the molecular conformation in the new polymorph are close to those in the previously known alpha-polymorph, but the packing of the z-shaped molecular ribbons linked by hydrogen bonds inherits that of the epsilon-form and is different from the packing in the alpha-polymorph. A structural study of the alpha-polymorph in the same temperature range has revealed no phase transitions.

Citations

Apr 1, 2011·Journal of Pharmaceutical Sciences·Harry G Brittain
Sep 5, 2015·Chemistry : a European Journal·Elena V BoldyrevaBoris A Zakharov
Dec 20, 2013·Chemical Reviews·Aurora J Cruz-Cabeza, Joel Bernstein
May 8, 2019·Acta Crystallographica. Section C, Structural Chemistry·Alexey Yu FedorovElena V Boldyreva
Oct 10, 2018·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·Anna Makal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta Crystallographica. Section C, Crystal Structure Communications
Tatiana N DrebushchakElena V Boldyreva
Acta Crystallographica. Section B, Structural Science
Tatiana N DrebushchakElena V Boldyreva
Acta Crystallographica. Section C, Crystal Structure Communications
Tatiana N DrebushchakElena V Boldyreva
© 2022 Meta ULC. All rights reserved