A congenic line of the C57BL/6J mouse strain that is proficient in melatonin synthesis

Journal of Pineal Research
Zhijing ZhangChristophe P Ribelayga

Abstract

The C57BL/6J (B6) is the most common inbred mouse strain used in biomedical research in the United States. Yet, this strain is notoriously known for being deficient in the biosynthesis of melatonin, an important effector of circadian clocks in the brain and in the retina. Melatonin deficiency in this strain results from nonfunctional alleles of the genes coding 2 key enzymes of the melatonin synthesis pathway: arylalkylamine-N-acetyltransferase (Aanat) and N-acetylserotonin-O-methyltransferase (Asmt). By introducing functional alleles of the Aanat and Asmt genes from the melatonin-proficient CBA/CaJ (CBA) mouse strain to B6, we have generated a B6 congenic line that has acquired the capacity of rhythmic melatonin synthesis. In addition, the melatonin-dependent rhythm of dopamine release in the retina is restored in the B6 congenic line. Finally, we have partially characterized the Aanat and Asmt genes of the CBA strain and have identified multiple differences between CBA and B6 alleles, including single nucleotide polymorphism and deletion/insertion of DNA segments of various sizes. As an improved model organism with functional components of the melatonin synthesis pathway and melatonin-dependent circadian regulations, the new ...Continue Reading

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Citations

Jun 15, 2019·Chronobiology International·David J Kennaway
Nov 14, 2019·Cancer Control : Journal of the Moffitt Cancer Center·David J Kennaway
Oct 3, 2018·The European Journal of Neuroscience·Gladys Y-P Ko
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Dec 2, 2020·Biology·Katya FrazierVanessa A Leone
Sep 17, 2020·Science Advances·Nange JinChristophe P Ribelayga
Jul 30, 2021·Journal of Biological Rhythms·Alex V Huynh, Ethan D Buhr

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