A consensus approach to diagnosing coronary artery disease based on clinical and exercise test data

Chest
D DoV F Froelicher

Abstract

To demonstrate that a consensus approach for combining prediction equations based on clinical and exercise test variables derived from different populations can stratify patients referred for possible coronary artery disease (CAD) into low-, intermediate-, and high-risk groups. Retrospective analysis of consecutive patients with complete data from exercise testing and coronary angiography referred for evaluation of possible CAD. After derivation of a logistic equation in our own training set of patients, this equation, along with two other equations developed independently by other investigators, was validated in a test set. The validation strategy for the consensus approach included the following: (1) calculation of probability scores for each patient using each logistic equation independently; (2) determination of probability thresholds in the training set to divide the patients into three groups-low risk (prevalence CAD <5%), intermediate risk (5 to 70%), and high risk (>70% prevalence of CAD); (3) using agreement among at least two of three of the prediction equations to generate "consensus" for each patient; and (4) application of the consensus approach thresholds to the test set of patients. Two university-affiliated Vete...Continue Reading

References

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Citations

Mar 14, 2002·Clinical Cardiology·William F FearonVictor F Froelicher
Jul 12, 2002·Diabetes/metabolism Research and Reviews·Euan A AshleyVictor Froelicher
Nov 4, 2000·Computers in Biology and Medicine·S J WangR L Kennedy
May 11, 2001·Primary Care·R D White, C H Evans
Nov 15, 2000·Lancet·E A AshleyV Froelicher
Dec 12, 2001·Journal of the American College of Cardiology·K ShetlerJ Myers
Jun 8, 2001·Sports Medicine·K ShetlerV Froelicher
Nov 13, 1999·Chest·V F FroelicherJ E Atwood
Jul 1, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Frederik VossRuediger Becker
Jun 10, 2009·Clinics in Sports Medicine·Siddhartha S Angadi, Glenn A Gaesser
Oct 10, 2002·The American Journal of Cardiology·Deborah B DiercksEzra A Amsterdam
Sep 25, 2016·QJM : Monthly Journal of the Association of Physicians·I ZeljkovicI Kruljac
Jun 7, 2002·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Michael LipinskiVictor Froelicher
May 21, 1999·Postgraduate Medicine·D A Driggers, D Marchant
Aug 8, 2002·Medicine and Science in Sports and Exercise·Euan AshleyVictor Froelicher
May 25, 2002·Progress in Cardiovascular Diseases·Victor FroelicherEuan Ashley

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