DOI: 10.1101/488460Dec 7, 2018Paper

A consensus molecular classification of muscle-invasive bladder cancer

BioRxiv : the Preprint Server for Biology
Aurelie KamounThe Bladder Cancer Molecular Taxonomy Group

Abstract

Muscle-Invasive Bladder Cancer (MIBC) is a molecularly diverse disease with heterogeneous clinical outcomes. Several molecular classifications have been proposed, yielding diverse sets of subtypes. This diversity hampers the clinical application of such knowledge. Here, we report the results of a large international effort to reach a consensus on MIBC molecular subtypes. Using 1750 MIBC transcriptomes and a network-based analysis of six independent MIBC classification systems, we identified a consensus set of six molecular classes: Luminal Papillary (24%), Luminal Non-Specified (8%), Luminal Unstable (15%), Stroma-rich (15%), Basal/Squamous (35%), and Neuroendocrine-like (3%). These consensus classes differ regarding underlying oncogenic mechanisms, infiltration by immune and stromal cells, and histological and clinical characteristics. This consensus system offers a robust framework that will enable testing and validating predictive biomarkers in future clinical trials.

Related Concepts

Biological Markers
Carcinoma, Basosquamous
Classification
Clinical Trials
Oncogenes
Stromal Cells
Neuroendocrine Tumors
Infiltration
Subtype (Attribute)
Luminal Region

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