A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans

Science
Needhi Bhalla, Abby F Dernburg

Abstract

We report the discovery of a checkpoint that monitors synapsis between homologous chromosomes to ensure accurate meiotic segregation. Oocytes containing unsynapsed chromosomes selectively undergo apoptosis even if a germline DNA damage checkpoint is inactivated. This culling mechanism is specifically activated by unsynapsed pairing centers, cis-acting chromosome sites that are also required to promote synapsis in Caenorhabditis elegans. Apoptosis due to synaptic failure also requires the C. elegans homolog of PCH2, a budding yeast pachytene checkpoint gene, which suggests that this surveillance mechanism is widely conserved.

References

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Related Concepts

Calcinus elegans
Cyartonema elegans
Coleonyx elegans
Cestrum elegans
Clarkia unguiculata
Clathrulina elegans
Apoptosis, Intrinsic Pathway
Cardioglossa elegans
Cymbella elegans
Cyrenella elegans

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