A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans

Needhi Bhalla, Abby F Dernburg


We report the discovery of a checkpoint that monitors synapsis between homologous chromosomes to ensure accurate meiotic segregation. Oocytes containing unsynapsed chromosomes selectively undergo apoptosis even if a germline DNA damage checkpoint is inactivated. This culling mechanism is specifically activated by unsynapsed pairing centers, cis-acting chromosome sites that are also required to promote synapsis in Caenorhabditis elegans. Apoptosis due to synaptic failure also requires the C. elegans homolog of PCH2, a budding yeast pachytene checkpoint gene, which suggests that this surveillance mechanism is widely conserved.


Mar 3, 2012·Cellular and Molecular Life Sciences : CMLS·Yosuke IchijimaSatoshi H Namekawa
Jun 18, 2009·Apoptosis : an International Journal on Programmed Cell Death·Tracy L PritchettKimberly McCall
Jul 9, 2013·Cell Death and Differentiation·Nicola SilvaAdriana La Volpe
Feb 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·G Valentin BörnerNancy Kleckner
Feb 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Adele AdamoAdriana La Volpe
Oct 17, 2008·Molekuliarnaia biologiia·J Y Wu, G S Yamg
Feb 8, 2006·PLoS Genetics·Peter M CarltonAbby F Dernburg
Dec 6, 2008·PLoS Genetics·Sara Andux, Ronald E Ellis
Jul 25, 2009·PLoS Genetics·Drew Thacker, Scott Keeney
Dec 14, 2011·PloS One·Anna KouznetsovaChrister Höög
Jan 24, 2012·Genetics·Philip M MeneelyJudith L Yanowitz
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Cheng ChenEric E Alani
Feb 18, 2012·Annual Review of Physiology·Cathleen M Lake, R Scott Hawley
Jan 7, 2010·Nature Reviews. Genetics·Mary Ann Handel, John C Schimenti

Related Concepts

Calcinus elegans
Cyartonema elegans
Coleonyx elegans
Cestrum elegans
Clarkia unguiculata
Clathrulina elegans
Apoptosis, Intrinsic Pathway
Cardioglossa elegans
Cymbella elegans
Cyrenella elegans

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Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis