A Conserved Distal Lung Regenerative Pathway in Acute Lung Injury

The American Journal of Pathology
Martin S TaylorRichard L Kradin

Abstract

Improved tools have led to a burgeoning understanding of lung regeneration in mice, but it is not yet known how these insights may be relevant to acute lung injury in humans. We report in detail two cases of fulminant idiopathic acute lung injury requiring extracorporeal membrane oxygenation in previously healthy young adults with acute respiratory distress syndrome, one of whom required lung transplantation. Biopsy specimens showed diffuse alveolar injury with a striking paucity of alveolar epithelial regeneration, rare hyaline membranes, and diffuse contiguous airspace lining by macrophages. This novel constellation was termed diffuse alveolar injury with delayed epithelization. In addition, mirroring data from murine models of lung injury/regeneration, peribronchiolar basaloid pods (previously described as squamous metaplasia) and ciliated bronchiolarization were identified in these patients and in 39% of 57 historical cases with diffuse alveolar damage. These findings demonstrate a common and clinically relevant human disease correlate for murine models of severe acute lung injury. Evidence suggests that peribronchiolar basaloid pods and bronchiolarization are related spatially and temporally and likely represent overlappin...Continue Reading

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Jul 12, 2017·American Journal of Respiratory and Critical Care Medicine·Martin S TaylorRichard L Kradin

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Citations

Sep 6, 2018·American Journal of Respiratory and Critical Care Medicine·Renat Shaykhiev
Mar 26, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chetan K RaneAndrew E Vaughan
Jun 21, 2019·Nature Reviews. Molecular Cell Biology·Jarod A Zepp, Edward E Morrisey
Apr 4, 2019·Thorax·John-Poul Ng-BlichfeldtMatthew Hind
Mar 27, 2020·International Journal of Molecular Sciences·Raanan BulvikShulamit B Wallach-Dayan
Oct 17, 2020·Stem Cell Reports·Maria Fernanda de Mello CostaAndrew E Vaughan
Jan 30, 2021·American Journal of Respiratory and Critical Care Medicine·Jenna O MillerJennifer L Goldman
Aug 4, 2021·The Journal of Clinical Investigation·Kangyun WuMichael J Holtzman

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