Apr 5, 2020

ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming

BioRxiv : the Preprint Server for Biology
F. LiD. Gao


While cancer is commonly perceived as a disease of dedifferentiation, the hallmark of early stage prostate cancer is paradoxically the loss of more plastic basal cells and the abnormal proliferation of more differentiated secretory luminal cells. However, the mechanism of prostate cancer pro-luminal differentiation is largely unknown. Through integrating analysis of the transcription factors (TFs) from 806 human prostate cancers, we have identified that ERG highly correlated with prostate cancer luminal subtyping. ERG overexpression in luminal epithelial cells inhibits its normal plasticity to transdifferentiate into basal lineage and ERG supersedes PTEN-loss which favors basal differentiation. ERG knock-out disrupted prostate cell luminal differentiation, whereas AR knock-out had no such effects. Trp63 is a known master regulator of prostate basal lineage. Through analysis of 3D chromatin architecture, we found that ERG binds and inhibits the enhancer activity and chromatin looping of a Trp63 distal enhancer, thereby silencing its gene expression. Specific deletion of the distal ERG binding site resulted in the loss of ERG-mediated inhibition of basal differentiation. Thus, ERG orchestrates chromatin interactions and regulates...Continue Reading

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Mentioned in this Paper

Eukaryotic Initiation Factor-4G
Norovirus (antigen)
Carboxy-Terminal Amino Acid
Amino Acids, I.V. solution additive
Complex (molecular entity)
Eukaryotic Initiation Factor-4A
Protein Biosynthesis

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