PMID: 9638342Jun 25, 1998Paper

A conserved role for L1 as a transmembrane link between neuronal adhesion and membrane cytoskeleton assembly

Cell Adhesion and Communication
M HortschR R Dubreuil

Abstract

The L1-family of cell adhesion molecules is involved in many important aspects of nervous system development. Mutations in the human L1-CAM gene cause a complicated array of neurological phenotypes; however, the molecular basis of these effects cannot be explained by a simple loss of adhesive function. Human L1-CAM and its Drosophila homolog neuroglian are rather divergent in sequence, with the highest degree of amino acid sequence conservation between segments of their cytoplasmic domains. In an attempt to elucidate the fundamental functions shared between these distantly related members of the L1-family, we demonstrate here that the extracellular domains of mammalian L1-CAMs and Drosophila neuroglian are both able to induce the aggregation of transfected Drosophila S2 cells in vitro. To a limited degree they even interact with each other in cell adhesion and neurite outgrowth assays. The cytoplasmic domains of human L1-CAM and neuroglian are both able to interact with the Drosophila homolog of the cytoskeletal linker protein ankyrin. Moreover the recruitment of ankyrin to cell-cell contacts is completely dependent on L1-mediated cell adhesion. These findings support a model of L1 function in which the phenotypes of human L1-C...Continue Reading

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Citations

Nov 9, 2006·The Journal of Membrane Biology·Ronald R Dubreuil
Mar 1, 2012·Cell and Tissue Research·Michael K E Schäfer, Michael Frotscher
Jan 21, 2000·Brain Research. Molecular Brain Research·C S RicardM R Hernandez
Apr 5, 2000·Progress in Retinal and Eye Research·M R Hernandez
Jan 14, 2004·Molecular Biology of the Cell·Rafique IslamMichael Hortsch
Jan 28, 2005·The European Journal of Neuroscience·Shira KnafoCésar Venero
Feb 26, 2016·Frontiers in Cell and Developmental Biology·Iryna Leshchyns'ka, Vladimir Sytnyk
Dec 6, 2003·The Journal of Cell Biology·Kazunari NishimuraHiroyuki Kamiguchi
Jan 6, 2004·Journal of Neuroscience Research·César VeneroCarmen Sandi
Dec 21, 2004·Molecular and Cellular Neurosciences·Lars V KristiansenLuis Garcia-Alonso
Jun 9, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Marco BlessmannJakob R Izbicki
Jan 28, 2014·Experimental Cell Research·Marie-Marcelle Trinh-Trang-TanEkaterini Kordeli
Jun 9, 2016·Progress in Histochemistry and Cytochemistry·Timur R SamatovAlexander G Tonevitsky
Jun 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K L Crossin, L A Krushel
Nov 26, 2002·The Journal of Biological Chemistry·Ying-Zhi XuJorgen Johansen
Dec 5, 1998·The Journal of Biological Chemistry·J D MalhotraM Hortsch
Jun 29, 2000·The Journal of Biological Chemistry·G Jefford, R R Dubreuil

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