A Contactless and Biocompatible Approach for 3D Active Microrobotic Targeted Drug Delivery

Micromachines
Federico OngaroSarthak Misra

Abstract

As robotic tools are becoming a fundamental part of present day surgical interventions, microrobotic surgery is steadily approaching clinically-relevant scenarios. In particular, minimally invasive microrobotic targeted drug deliveries are reaching the grasp of the current state-of-the-art technology. However, clinically-relevant issues, such as lack of biocompatibility and dexterity, complicate the clinical application of the results obtained in controlled environments. Consequently, in this work we present a proof-of-concept fully contactless and biocompatible approach for active targeted delivery of a drug-model. In order to achieve full biocompatiblity and contacless actuation, magnetic fields are used for motion control, ultrasound is used for imaging, and induction heating is used for active drug-model release. The presented system is validated in a three-dimensional phantom of human vessels, performing ten trials that mimic targeted drug delivery using a drug-coated microrobot. The system is capable of closed-loop motion control with average velocity and positioning error of 0.3 mm/s and 0.4 mm, respectively. Overall, our findings suggest that the presented approach could augment the current capabilities of microrobotic ...Continue Reading

References

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Jan 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Feng GuoTony Jun Huang
Feb 1, 2015·Proceedings of the IEEE·Metin SittiEric Diller
Oct 31, 2017·Journal of Micro-bio Robotics·Federico OngaroSarthak Misra
Jul 1, 2017·Frontiers in Mechanical Engineering·Arijit GhoshDavid H Gracias

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Citations

Dec 29, 2020·Proceedings. Mathematical, Physical, and Engineering Sciences·Sumit MohantySarthak Misra
Sep 2, 2020·ACS Nano·Azaam AzizOliver G Schmidt

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Methods Mentioned

BETA
imaging techniques

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