A contemporary profile of primary progressive multiple sclerosis participants from the NARCOMS Registry

Multiple Sclerosis : Clinical and Laboratory Research
Amber SalterRuth Ann Marrie

Abstract

Primary progressive multiple sclerosis (PPMS) represents 10%-15% of all multiple sclerosis (MS) diagnoses. Information regarding socio-demographic and clinical characteristics of persons with PPMS is limited. To characterize persons with PPMS in the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry. We compared demographic and health-related characteristics of NARCOMS Registry participants reporting PPMS in the spring 2015 update survey with those reporting relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS), with characteristics of published PPMS cohorts. Of 8004 responders, 6774 self-reported a clinical course of PPMS, SPMS, or RRMS. The PPMS cohort ( n = 632, 9.3%) reported a mean (standard deviation (SD)) age of 64.3 (8.9) years; 62.7% were female; the SPMS and RRMS cohorts were younger and had a higher proportion of females. The NARCOMS PPMS cohort differed in age, time from onset and diagnosis, and proportion of females compared to population-based and clinical trial cohorts. Median (25%, 75%) number of comorbidities was 2 (1, 2) for each cohort with vascular comorbidities being most frequently reported. The NARCOMS population provides a different pers...Continue Reading

Associated Clinical Trials

References

Jun 1, 1997·Brain : a Journal of Neurology·A J ThompsonJ De Sá
Sep 25, 2003·JAMA : the Journal of the American Medical Association·Sean R TunisCarolyn M Clancy
Jul 29, 2005·Brain : a Journal of Neurology·S J CampD W Langdon
Dec 29, 2005·Neurology·Helen TremlettVirginia Devonshire
Jan 18, 2006·Brain : a Journal of Neurology·Christian Confavreux, Sandra Vukusic
Apr 26, 2006·Neurology·R A MarrieD Campagnolo
May 26, 2007·Multiple Sclerosis : Clinical and Laboratory Research·R A MarrieT Vollmer
Jun 21, 2007·Journal of Neurology·M DebouverieH Vespignani
Jun 30, 2007·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Sheri L PoharKenneth Warren
Jul 26, 2008·Multiple Sclerosis : Clinical and Laboratory Research·R VazirinejadC Ward
Dec 10, 2009·Neurology·Marcus KochHelen Tremlett
Jun 17, 2010·Neuroepidemiology·Myles HortonRuth Ann Marrie
Oct 1, 2010·Acta Neurologica Scandinavica·R A MarrieT Vollmer
May 16, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Katharine E HardingNeil P Robertson
Dec 3, 2014·Journal of the Neurological Sciences·Prudence TetteyIngrid A F van der Mei
Dec 24, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Ruth Ann MarriePer Soelberg Sorensen
Apr 29, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M MocciaV Brescia Morra
Dec 15, 2015·International Journal of MS Care·Aida RaissiScott B Patten
Mar 11, 2016·Neurology·Ruth Ann MarrieUNKNOWN CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis
Nov 17, 2016·Neurology. Clinical Practice·Amber SalterRuth Ann Marrie
Dec 22, 2016·The New England Journal of Medicine·Xavier MontalbanUNKNOWN ORATORIO Clinical Investigators
Jan 13, 2017·PloS One·Andrius KavaliunasJan Hillert

❮ Previous
Next ❯

Citations

Dec 30, 2017·BMC Health Services Research·Antoni Sicras-MainarJorge Maurino
Jun 17, 2018·Annals of Neurology·Xiaoming JiaSergio E Baranzini
Aug 23, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y ZhangI van der Mei
Jun 18, 2019·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Francisco Pérez-MirallesBonaventura Casanova-Estruch
Sep 4, 2020·Journal of Neurology·Lara Marie Pangan LoIngrid van der Mei
Mar 18, 2020·Multiple Sclerosis and Related Disorders·Jorge MaurinoUNKNOWN W-IMPACT Study Group

❮ Previous
Next ❯

Software Mentioned

SASv9

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved