A Contemporary Prostate Biopsy Risk Calculator Based on Multiple Heterogeneous Cohorts.

European Urology
Donna P AnkerstAndrew J Vickers

Abstract

Prostate cancer prediction tools provide quantitative guidance for doctor-patient decision-making regarding biopsy. The widely used online Prostate Cancer Prevention Trial Risk Calculator (PCPTRC) utilized data from the 1990s based on six-core biopsies and outdated grading systems. We prospectively gathered data from men undergoing prostate biopsy in multiple diverse North American and European institutions participating in the Prostate Biopsy Collaborative Group (PBCG) in order to build a state-of-the-art risk prediction tool. We obtained data from 15 611 men undergoing 16 369 prostate biopsies during 2006-2017 at eight North American institutions for model-building and three European institutions for validation. We used multinomial logistic regression to estimate the risks of high-grade prostate cancer (Gleason score ≥7) on biopsy based on clinical characteristics, including age, prostate-specific antigen, digital rectal exam, African ancestry, first-degree family history, and prior negative biopsy. We compared the PBCG model to the PCPTRC using internal cross-validation and external validation on the European cohorts. Cross-validation on the North American cohorts (5992 biopsies) yielded the PBCG model area under the receive...Continue Reading

Associated Clinical Trials

Citations

Apr 26, 2019·The Cochrane Database of Systematic Reviews·Frank-Jan H DrostIvo G Schoots
Oct 17, 2019·BMC Medical Research Methodology·Johanna TolksdorfDonna P Ankerst
Jul 10, 2020·Prostate Cancer and Prostatic Diseases·Hari T VigneswaranMichael R Abern
Sep 10, 2020·Postgraduate Medicine·William W French, Eric M Wallen
Jul 6, 2020·BMC Medical Informatics and Decision Making·Amirhossein JalaliR William Watson
Aug 12, 2018·Advances in Therapy·Samuel W D MerrielWillie Hamilton
Nov 11, 2020·Prostate Cancer and Prostatic Diseases·Hari T VigneswaranTobias Nordström
Apr 21, 2021·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Julia Hippisley-Cox, Carol Coupland
Aug 1, 2021·BMC Medical Informatics and Decision Making·Ruoyu LiuCi-Ren Guo
Sep 4, 2021·JMIR Cancer·Antonio Bandala-JacquesNancy Reynoso-Noverón

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