A contemporary review of management and prognostic factors of upper tract urothelial carcinoma

Cancer Treatment Reviews
Jeffrey J LeowJoaquim Bellmunt

Abstract

Upper tract urothelial carcinoma (UTUC) accounts for <5% of all urothelial cancers. Although the main treatment is radical nephroureterectomy (NU), oncologic outcomes are not comparable to lower tract urothelial cancers. Identifying prognostic factors can help guide management and potentially improve outcomes. This article systematically reviews current literature on prognostic factors and management options for UTUC. A comprehensive literature search was performed to identify all studies examining prognostic factors and management options for UTUC. The search included the Medline, Embase, Cochrane Central Register of Controlled Trials databases, and abstracts from the American Society of Clinical Oncology meetings up to November 2014. An updated systematic review was performed. Preoperative prognostic factors for UTUC patients include age, race, performance status, obesity, smoking status, elevated fibrinogen levels, hydronephrosis, tumor size, multi-focality, location, clinical grade and previous/synchronous bladder cancer. Postoperative variables include tumor stage/grade, multifocality, nodal involvement, lympho-vascular invasion, initial ureteral location, necrosis, sessile architecture, variant histologies and presence of...Continue Reading

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Citations

Oct 19, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Sung Gu KangJun Cheon
Jan 10, 2017·Urologic Oncology·Andrew CohenSangtae Park
Mar 3, 2020·Japanese Journal of Clinical Oncology·Junichi InokuchiYoshihiko Tomita
Mar 3, 2017·Current Urology Reports·Daniel P VergesDemetrius H Bagley
Oct 14, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Subo QianHaibo Shen
Dec 8, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Junichi InokuchiUNKNOWN Urologic Oncology Study Group of the Japan Clinical Oncology Group (JCOG)

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