PMID: 16614409Apr 15, 2006Paper

A continuous dietary supply of free calcium formate negatively affects the parietal cell population and gastric RNA expression for H+/K+-ATPase in weaning pigs

The Journal of Nutrition
Paolo BosiGiovanna Lalatta-Costerbosa

Abstract

Baby formula acidification can be used to reduce diarrhea. Calcium formate is a dietary acidifier frequently used in animal weaning diets; it is also a source of available calcium. Gastric acidification reduces gastrin release and hydrochloric acid (HCl) secretion. To study the medium-term effects on fundic gastric mucosa, we fed weaning pigs control diets or diets supplemented with free or fat-protected calcium formate. We evaluated the following: 1) the number of HCl-secreting parietal cells, by immunohistochemistry using an antibody against H(+)/K(+)-ATPase; 2) the number of enteroendocrine cells immunohistochemically stained with chromogranin A (CGA), somatostatin, and histamine (HIS); and 3) the expression of the H(+)/K(+)-ATPase gene, by real-time RT-PCR in the oxyntic mucosa. Cells co-staining for CGA and HIS were defined as enterochromaffin-like (ECL) cells. Pigs fed calcium formate had fewer parietal cells and a lower expression of the H(+)/K(+)-ATPase gene than the controls (P < 0.05). This reduction did not occur in pigs fed fat-protected calcium formate. Somatostatin immune-reactive cells were also more numerous in pigs fed free calcium formate than in controls (P < 0.05). The number of ECL cells was not affected. U...Continue Reading

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Citations

Oct 21, 2016·Veterinary Research·Guangzhi ZhangFreddy Haesebrouck
Dec 1, 2009·Animal : an International Journal of Animal Bioscience·J P LallèsD Torrallardona
Jul 26, 2011·Journal of Anatomy·Maurizio MazzoniGiovanna Lalatta-Costerbosa
Jul 22, 2008·The Journal of Nutrition·Maurizio MazzoniPaolo Bosi
May 23, 2020·Animals : an Open Access Journal From MDPI·Diana LuisePaolo Trevisi

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