A contractile electronic switch made of DNA

Journal of the American Chemical Society
Yu Chuan Huang, Dipankar Sen

Abstract

Double-helical DNA has been shown to conduct both electrons and electron holes, the latter over distances of >20 nm. DNA is thus a material of significant interest for the bottom-up construction of nanocircuitry. Here, we describe a contractile DNA nanoswitch, which can toggle between a structurally extended "off" state and a contracted "on" state, with a 40-fold conductivity difference between the two. To turn on, two short motifs of guanine-guanine mismatches in an otherwise standard double helix synapse to form a conductive G-quadruplex, bypassing an insulating element within the helix. This switch can be turned repeatedly on by treatment with millimolar concentrations of K(+) and turned off by sequestration of the K(+) by a crown ether. Circular dichroism and thymine-thymine photocross-linking experiments reveal that strand orientations within the on state G-quadruplex are wholly antiparallel and that the two conductive double-helices interface with the same face of the quadruplex. Although this DNA nanoswitch is chemically gated, it should be adaptable to other kinds of gating and thus serve as a prototype for increasingly sophisticated and complex electronic devices made of DNA.

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Citations

Apr 17, 2013·Bioorganic & Medicinal Chemistry·Ken-ichi HarunaKazuhito Tanabe
Jan 1, 2013·Nucleic Acids Research·Anh Tuân Phan, Ngoc Quang Do
Sep 18, 2012·Biosensors & Bioelectronics·Hui ZhouRu-Qin Yu
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Dec 17, 2014·Chemistry : a European Journal·Matteo NadaiMauro Freccero
Apr 1, 2015·Chemical Communications : Chem Comm·Liyun ZhangChi-Lik Ken Lee
Oct 22, 2014·Angewandte Chemie·Yu Chuan Huang, Dipankar Sen
Nov 28, 2018·Angewandte Chemie·Blaž BakalarAnh Tuân Phan
Nov 26, 2010·Angewandte Chemie·Bixia GeHua-Zhong Yu
Sep 9, 2011·Chemical Society Reviews·Jungkweon Choi, Tetsuro Majima
Oct 31, 2013·Chemical Society Reviews·Yiting TangHua-Zhong Yu
Apr 14, 2020·Nucleic Acids Research·Martina TassinariSara N Richter
Aug 6, 2010·The Journal of Physical Chemistry. B·Kiyohiko KawaiTetsuro Majima
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Aug 31, 2011·Journal of the American Chemical Society·Kiyohiko KawaiTetsuro Majima
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May 29, 2019·Analytical Chemistry·Fen MaHua-Zhong Yu
Sep 7, 2013·Journal of the American Chemical Society·Wei TangFeng Liu

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