PMID: 7030902Sep 1, 1981Paper

A controlled clinical trial of the efficacy of the hepatitis B vaccine (Heptavax B): a final report

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
W SzmunessA Kellner

Abstract

A controlled, randomized, double-blind trial in 1,083 homosexual men from New York confirmed that a highly purified, formalin-inactivated vaccine against hepatitis B prepared from HBsAg positive plasma, is safe immunogenic, and highly efficacious. Over 95% of vaccinated subjects developed antibody against the surface antigen. Vaccine-induced antibody persisted for the entire 24-month follow-up period. The attack rate of all hepatitis B virus infections (excluding conversions of anti-HBc alone) was 3.2% in vaccine recipients compared with 25.6% in placebo recipients (p less than 0.0001). In those who received all three doses of vaccine, of 40 micrograms each, the protective efficacy rate was close to 100%. The vaccine protects against acute hepatitis B, asymptomatic infection, and chronic antigenemia. There is reason to assume that the vaccine is also partially effective when given postexposure.

References

Jul 1, 1977·Science·B S Blumberg
Sep 1, 1975·The American Journal of the Medical Sciences·M R HillemanG P Lampson
Oct 1, 1975·Annals of Internal Medicine·W SzmunessG H Block
Feb 1, 1981·Seminars in Liver Disease·L B Seeff
Feb 5, 1981·The New England Journal of Medicine·P Delaney
Feb 1, 1981·American Journal of Epidemiology·W SzmunessE J Harley

❮ Previous
Next ❯

Citations

Dec 1, 1996·Journal of Medical Virology·J N Zuckerman
Sep 25, 1999·Journal of Cellular Physiology·M A Feitelson
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M F YuenC L Lai
Oct 1, 1994·Journal of Medical Virology·F E André, A J Zuckerman
May 1, 1986·Journal of General Internal Medicine·S M Lemon, D J Weber
May 1, 1987·Indian Journal of Pediatrics·R S Festa
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·A SebastianiO M Mohamud
Jul 1, 1986·Journal of Biological Standardization·W Frisch-NiggemeyerH Hofmann
Dec 1, 1983·Vaccine·L Y HwangW Szmuness
Jan 1, 1993·Vaccine·A R ZanettiI Grappasonni
Jan 1, 1989·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S Sklavounou-TsouroutsoglouJ Papapanayotou
Nov 24, 1984·Lancet·W JilgF Deinhardt
Jan 8, 2004·Journal of Hepatology·Daniel Shouval

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.