PMID: 8454793Mar 1, 1993Paper

A controlled dose-response study of immunotherapy with standardized, partially purified extract of house dust mite: clinical efficacy and side effects

The Journal of Allergy and Clinical Immunology
L HaugaardL Jacobsen

Abstract

Seventy-four asthmatic patients allergic to house dust mite were included in a double-blind, controlled study to establish the optimal maintenance dose of a standardized extract of Dermatophagoides pteronyssinus (Der p I) during 24 months of immunotherapy (IT). The patients were given the following maintenance doses: 19 patients 10,000 standardized quality units (SQ-U) (group 10, 0.7 microgram Der p I), 20 patients 100,000 SQ-U (group 100, 7 micrograms Der p I), 16 patients 300,000 SQ-U (group 300, 21 micrograms Der p I), and 19 control patients (group 0) had no injections. After 24 months bronchial challenge demonstrated a dose-related increased tolerance to Der p I, group 10 (p = 0.003), group 100 (p = 0.0005), group 300 (p = 0.0007), with no change in group 0 (p = 0.6). Patients given IT had a decrease in medication and peak expiratory flow score. In total, 2104 injections were given, and 3.5% were followed by a systemic reaction, defined as a fall 15% or greater in forced expiratory volume in 1 second within 30 minutes. A dose-response relation was demonstrated, with rates of systemic reactions in percent of injections; group 10, 0.56%; group 100, 3.30%; and group 300, 7.10% (p < 0.0001). No anaphylactic reactions occurred,...Continue Reading

Citations

Sep 14, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·O Pfaar, L Klimek
Mar 15, 2002·Current Allergy and Asthma Reports·H Løwenstein, J N Larsen
Mar 15, 2002·Current Allergy and Asthma Reports·R E Esch, J Portnoy
Jun 1, 2013·Current Allergy and Asthma Reports·Robert E Esch, Greg A Plunkett
Feb 11, 2000·The Journal of Allergy and Clinical Immunology·P S Creticos
Sep 13, 2001·Veterinary Immunology and Immunopathology·C E Griffin, A Hillier
Oct 1, 2004·Allergologia et immunopathologia·A Iglesias-CadarsoA Pérez-Pimiento
Jul 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·P S Creticos
Jul 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·L M DuBuske
Mar 27, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·B J Rhodes
Jun 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D MunganL Gürbüz
Feb 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·P Sharkey, J Portnoy
Oct 28, 1999·Allergy·M AbramsonJ Weiner
Jul 18, 2002·Allergy·A Ferrer, J García-Sellés
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W GruberM S Zach
Aug 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L FrølundR Pauwels
Oct 3, 2008·Clinical Allergy and Immunology·Ines SwobodaMonika Grote
Jun 16, 2005·International Archives of Allergy and Immunology·Miguel CasanovasAntonio Basomba
Dec 24, 2005·International Archives of Allergy and Immunology·M CasanovasE Fernández-Caldas
Jul 21, 2007·International Archives of Allergy and Immunology·Peter Adler WürtzenHelene Henmar
Sep 18, 2010·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Luis PrietoRocio Rojas
May 10, 2013·Clinical and Translational Allergy·Juliane Rieker-SchwienbacherJörg Kleine-Tebbe
Feb 19, 2013·Immunotherapy·Nerin Nadir BahcecilerNazan Cobanoglu
Nov 1, 2005·Expert Review of Clinical Immunology·Linda Cox
Jul 1, 2006·Expert Review of Clinical Immunology·Linda Cox
Oct 16, 2015·International Forum of Allergy & Rhinology·Frederick M SchafferAndrew R Naples
Feb 13, 2016·Science Translational Medicine·Rachael JarrettGraham Ogg
Oct 29, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·H J Malling
Aug 1, 2015·The American Journal of the Medical Sciences·Jie HanMu-Kui Wang
Oct 22, 2013·The Journal of Allergy and Clinical Immunology·Moises A CalderonPascal Demoly
Oct 25, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Désirée Larenas-LinnemannDerek Constable

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Related Papers

The Journal of Allergy and Clinical Immunology
P S CreticosP S Norman
The Journal of Allergy and Clinical Immunology
T E Van MetreG L Rosenberg
© 2021 Meta ULC. All rights reserved